{"title":"正电子发射断层扫描结果在前纵隔肿瘤治疗中的实用性。","authors":"Akihiko Kitami, Fumitoshi Sano, Shinichi Ohashi, Kosuke Suzuki, Shugo Uematsu, Takashi Suzuki, Mitsutaka Kadokura","doi":"10.5761/atcs.oa.16-00205","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>We performed a retrospective analysis to evaluate the usefulness of positron-emission tomography/computed tomography (PET/CT) findings in the classification and management of anterior mediastinal tumors.</p><p><strong>Methods: </strong>Between 2006 and 2015, 105 patients with anterior mediastinal tumor received PET/CT. <sup>18</sup>F-fluorodeoxyglucose (<sup>18</sup>F-FDG)-PET images were obtained 60 minutes after the injection of <sup>18</sup>F-FDG.</p><p><strong>Results: </strong>The histological classifications were as follows: thymoma (n = 49), thymic carcinoma (TC) (n = 19), malignant lymphoma (ML) (n = 8), teratoma (n = 7), thymic cyst (n = 14), and others (n = 8). Upon visual inspection (SUV max: >2.0), all of the malignant tumors showed <sup>18</sup>F-FDG accumulation (with the exception of one type A thymoma). Two of the 14 thymic cysts and three of the seven teratomas showed slight <sup>18</sup>F-FDG accumulation. The SUV max values of the low-grade thymomas, high-grade thymomas, TCs and MLs were 3.14 ± 0.73, 4.34 ± 1.49, 8.59 ± 3.05, and 10.08 ± 2.53, respectively, with significant differences between the low- and high-grade thymomas, and between TCs and MLs. The sensitivity, specificity and accuracy of <sup>18</sup>F-FDG in the detection of low-grade thymomas and thymomas with a maximum diameter of ≤50 mm and an SUV max of ≤3.4 were 85%, 48%, and 60%, respectively.</p><p><strong>Conclusion: </strong>FDG-PET/CT is an objective and useful modality in the differential diagnosis and management of anterior mediastinal tumors.</p>","PeriodicalId":93877,"journal":{"name":"Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2017-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347484/pdf/","citationCount":"0","resultStr":"{\"title\":\"The Usefulness of Positron-Emission Tomography Findings in the Management of Anterior Mediastinal Tumors.\",\"authors\":\"Akihiko Kitami, Fumitoshi Sano, Shinichi Ohashi, Kosuke Suzuki, Shugo Uematsu, Takashi Suzuki, Mitsutaka Kadokura\",\"doi\":\"10.5761/atcs.oa.16-00205\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>We performed a retrospective analysis to evaluate the usefulness of positron-emission tomography/computed tomography (PET/CT) findings in the classification and management of anterior mediastinal tumors.</p><p><strong>Methods: </strong>Between 2006 and 2015, 105 patients with anterior mediastinal tumor received PET/CT. <sup>18</sup>F-fluorodeoxyglucose (<sup>18</sup>F-FDG)-PET images were obtained 60 minutes after the injection of <sup>18</sup>F-FDG.</p><p><strong>Results: </strong>The histological classifications were as follows: thymoma (n = 49), thymic carcinoma (TC) (n = 19), malignant lymphoma (ML) (n = 8), teratoma (n = 7), thymic cyst (n = 14), and others (n = 8). Upon visual inspection (SUV max: >2.0), all of the malignant tumors showed <sup>18</sup>F-FDG accumulation (with the exception of one type A thymoma). Two of the 14 thymic cysts and three of the seven teratomas showed slight <sup>18</sup>F-FDG accumulation. The SUV max values of the low-grade thymomas, high-grade thymomas, TCs and MLs were 3.14 ± 0.73, 4.34 ± 1.49, 8.59 ± 3.05, and 10.08 ± 2.53, respectively, with significant differences between the low- and high-grade thymomas, and between TCs and MLs. The sensitivity, specificity and accuracy of <sup>18</sup>F-FDG in the detection of low-grade thymomas and thymomas with a maximum diameter of ≤50 mm and an SUV max of ≤3.4 were 85%, 48%, and 60%, respectively.</p><p><strong>Conclusion: </strong>FDG-PET/CT is an objective and useful modality in the differential diagnosis and management of anterior mediastinal tumors.</p>\",\"PeriodicalId\":93877,\"journal\":{\"name\":\"Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-02-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347484/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5761/atcs.oa.16-00205\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2017/1/24 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5761/atcs.oa.16-00205","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2017/1/24 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
目的：我们进行了一项回顾性分析，评估正电子发射断层扫描/计算机断层扫描（PET/CT）结果在前纵隔肿瘤的分类和治疗中的作用：2006年至2015年间，105名前纵隔肿瘤患者接受了PET/CT检查。注射18F-脱氧葡萄糖（18F-FDG）60分钟后获得18F-FDG-PET图像：组织学分类如下：胸腺瘤（49 例）、胸腺癌（TC）（19 例）、恶性淋巴瘤（ML）（8 例）、畸胎瘤（7 例）、胸腺囊肿（14 例）和其他（8 例）。经肉眼观察（最大 SUV 值：>2.0），所有恶性肿瘤均显示有 18F-FDG 积累（一个 A 型胸腺瘤除外）。14 个胸腺囊肿中的 2 个和 7 个畸胎瘤中的 3 个有轻微的 18F-FDG 积聚。低级别胸腺瘤、高级别胸腺瘤、TC 和 ML 的 SUV max 值分别为（3.14±0.73）、（4.34±1.49）、（8.59±3.05）和（10.08±2.53），低级别和高级别胸腺瘤之间以及 TC 和 ML 之间差异显著。18F-FDG检测低级别胸腺瘤和最大直径≤50 mm、SUV max≤3.4的胸腺瘤的敏感性、特异性和准确性分别为85%、48%和60%：结论：FDG-PET/CT 是鉴别诊断和治疗前纵隔肿瘤的一种客观而有用的方法。
The Usefulness of Positron-Emission Tomography Findings in the Management of Anterior Mediastinal Tumors.
Purpose: We performed a retrospective analysis to evaluate the usefulness of positron-emission tomography/computed tomography (PET/CT) findings in the classification and management of anterior mediastinal tumors.
Methods: Between 2006 and 2015, 105 patients with anterior mediastinal tumor received PET/CT. 18F-fluorodeoxyglucose (18F-FDG)-PET images were obtained 60 minutes after the injection of 18F-FDG.
Results: The histological classifications were as follows: thymoma (n = 49), thymic carcinoma (TC) (n = 19), malignant lymphoma (ML) (n = 8), teratoma (n = 7), thymic cyst (n = 14), and others (n = 8). Upon visual inspection (SUV max: >2.0), all of the malignant tumors showed 18F-FDG accumulation (with the exception of one type A thymoma). Two of the 14 thymic cysts and three of the seven teratomas showed slight 18F-FDG accumulation. The SUV max values of the low-grade thymomas, high-grade thymomas, TCs and MLs were 3.14 ± 0.73, 4.34 ± 1.49, 8.59 ± 3.05, and 10.08 ± 2.53, respectively, with significant differences between the low- and high-grade thymomas, and between TCs and MLs. The sensitivity, specificity and accuracy of 18F-FDG in the detection of low-grade thymomas and thymomas with a maximum diameter of ≤50 mm and an SUV max of ≤3.4 were 85%, 48%, and 60%, respectively.
Conclusion: FDG-PET/CT is an objective and useful modality in the differential diagnosis and management of anterior mediastinal tumors.
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