多sinw - fet生物传感器对诺如病毒DNA和IgG的高灵敏度检测

2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS) Pub Date : 2015-06-21 DOI:10.1109/TRANSDUCERS.2015.7181230

X. Gong, R. Zhao, Xiaomei Yu

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引用次数: 8

摘要

本文报道了多硅纳米线场效应晶体管(SiNW-FET)生物传感器对DNA和蛋白质的超灵敏检测。单sinw - fet，双sinw - fet和四sinw - fet已经在单芯片上设计并通过简单的自上而下的制造工艺制造。与单sinw - fet相比，多sinw - fet生物传感器通过平均源漏电流来降低噪声的能力更高。诺如病毒DNA和IgG的检测浓度分别低至1fm和10fm。该传感器对1bp错配DNA干扰也有较高的特异性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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High sensitive detections of Norovirus DNA and IgG by using multi-SiNW-FET biosensors

This paper reports ultrasensitive detections of DNA and protein by multi-silicon-nanowire field-effect-transistor (SiNW-FET) biosensors. Single-SiNW-FET, double-SiNW-FET and quad-SiNW-FET have been designed on a single chip and fabricated by a simple top-down fabrication process. Compared with single-SiNW-FET, the multi-SiNW-FET biosensor shows a higher ability of decreasing the noise by averaging the source-drain currents. Both Norovirus DNA and IgG have been detected with the sensors at concentrations as low as 1 fM and 10 fM respectively. The sensor also shown high specificity in 1bp mismatch DNA disturbance.

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2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS)

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