一项初步研究表明，运动降低了炎症因子的浓度，但没有调节可能与高血压有关的表观遗传标志物的水平

IF 0.6 Q3 VETERINARY SCIENCES

Comparative Exercise Physiology Pub Date : 2023-05-21 DOI:10.3920/cep220037

T. R. Ramis, F. Boeno, D. Pochmann, S. V. Munhoz, A. Mallmann, Alvaro Reischak-Oliveira, V. Elsner

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引用次数: 0

摘要

由HAT和HDAC2酶介导的组蛋白乙酰化状态等表观遗传机制在高血压的病理生理、病因和进展中起着核心作用。体育锻炼的抗炎作用可能与组蛋白乙酰化状态的调节有关，这可能改变表观基因组，为高血压患者提供治疗益处。研究运动训练方案对高血压患者表观遗传参数(HAT活性和HDAC2浓度)、炎症标志物(白细胞介素(IL)-10、肿瘤坏死因子(TNF)-α和c反应蛋白(CRP))和心肺适能参数(vo2峰值、动态血压、NOx、内皮素1 (ET-1)、血流介导扩张、高密度脂蛋白(HDL)和三酰甘油水平)的影响。9例30 ~ 59岁的高血压患者每周进行3次力量或有氧运动，为期12周。在干预前后评估身体健康、24小时血压(收缩压和舒张压)、血流介导的血管舒张、血脂分析和生物标志物。由于HAT活性和HDAC2浓度在干预后保持不变，因此未发现表观遗传参数发生变化。vo2峰(术前:29.1±6.3，术后:31.5±6.3,P=0.021)和HDL(术前:41.4±9，术后:46.8±9.5,P=0.003)显著升高。此外，24小时收缩压和舒张压分别显著降低:(术前:119.1±5.6，术后:114.4±4.5,P=0.6;术前:73.9±4.1，术后:70.5±4.2,P=0.4)， CRP(术前:2.4±1.4;后置:1.2±0.7*，P=0.03)。最后，未发现IL-10和TNF-α的变化。在接受12周运动训练的高血压患者中，vo2峰值、24小时血压、HDL和CRP均有所改善。然而，HDAC2和HAT的浓度和活性均未见变化。

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Exercise reduced the concentration of an inflammatory makers without modulating the levels of epigenetic marker potentially involved in hypertension: a preliminary study

Epigenetic mechanisms such as histone acetylation status mediated by HAT and HDAC2 enzymes play a central role in the pathophysiology, etiology, and progression of hypertension. The anti-inflammatory effects of physical exercise may be related to the modulation of histone acetylation status, which may alter the epigenome, providing therapeutic benefits for hypertensive individuals. To investigate the effects of an exercise training protocol on epigenetic parameters (HAT activities and HDAC2 concentrations), inflammatory markers (interleukin (IL)-10, tumour necrosis factor (TNF)-α, and C-reactive protein (CRP)), and cardiopulmonary fitness parameters (VO2peak, ambulatory blood pressure, NOx, endothelin 1 (ET-1), flow-mediated dilation, high density lipoprotein (HDL), and triacylglycerol levels) in treated hypertensive patients. Nine hypertensive patients aged 30-59 years underwent 12 weeks of strength or aerobic exercise 3 times a week. Physical fitness, 24-h blood pressure (systolic and diastolic), flow-mediated vasodilation, blood lipid profile analysis, and biomarkers were assessed before and after the intervention. No alterations were found in epigenetic parameters since HAT activities and HDAC2 concentrations remained unchanged after the intervention. Significant increases were found in VO2peak (pre: 29.1±6.3 and post: 31.5±6.3, P=0.021) and HDL (pre: 41.4±9 and post: 46.8±9.5, P=0.003). Furthermore, a significant reduction was seen in 24-h systolic and diastolic blood pressure, respectively: (pre: 119.1±5.6 and post: 114.4±4.5, P=0.6; pre: 73.9±4.1 and post: 70.5±4.2, P=0.4) and in CRP (pre: 2.4±1.4; post: 1.2±0.7*, P=0.03). Lastly, no alterations were found in IL-10 and TNF-α. In treated hypertensive individuals undergoing 12 weeks of exercise training VO2peak, 24 h blood pressure, HDL, and CRP improved. However, changes were not found in concentrations and the activity of HDAC2 and HAT, respectively.

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来源期刊

Comparative Exercise Physiology VETERINARY SCIENCES-

CiteScore

1.50

自引率

11.10%

发文量

期刊介绍： ''Comparative Exercise Physiology'' is the only international peer-reviewed scientific journal specifically dealing with the latest research in exercise physiology across all animal species, including humans. The major objective of the journal is to use this comparative approach to better understand the physiological, nutritional, and biochemical parameters that determine levels of performance and athletic achievement. Core subjects include exercise physiology, biomechanics, gait (including the effect of riders in equestrian sport), nutrition and biochemistry, injury and rehabilitation, psychology and behaviour, and breeding and genetics. This comparative and integrative approach to exercise science ultimately highlights the similarities as well as the differences between humans, horses, dogs, and other athletic or non-athletic species during exercise. The result is a unique forum for new information that serves as a resource for all who want to understand the physiological challenges with exercise.