治疗性DNA疫苗:成功的最后一步

Journal of Bacteriology & Parasitology Pub Date : 2017-04-03 DOI:10.4172/2155-9597.1000E125

F. D. Carmo, R. Carvalho, G. Jan, V. Azevedo

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引用次数: 2

摘要

治疗性DNA疫苗主要是含有强启动子的质粒结构，允许一种或多种编码蛋白/抗原的原位转录和翻译，以诱导针对不同病原生物的保护性细胞和体液免疫反应[1-5]。目前，至少有114项开放的临床研究正在使用DNA疫苗方法招募不同临床阶段的患者。

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Therapeutic DNA Vaccines: The Final Step for Success

Therapeutic DNA vaccines are mostly plasmidic constructs containing a strong promoter that allows in situ transcription and translation of one or many encoded proteins/antigens to induce protective cellular and humoral immune responses against different pathogenic organisms [1–5]. Currently, at least 114 open clinical studies are recruiting patients for distinct clinical phases using a DNA vaccine approach.

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Journal of Bacteriology & Parasitology

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