种植牙周围的口腔癌:临床表现和致癌机制是否独特?

Gabriela Lopes Dos Santos, Kaique Preto Alberto, Silas Antonio Juvêncio de Freitas Filho, Kellen Cristine Tjioe, Denise Tostes Oliveira
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引用次数: 0

摘要

骨整合种植体已成为全牙或部分无牙患者牙科康复的最佳治疗选择。虽然种植体周围炎仍然是牙种植体失败最常见的局部危险因素,但涉及钛周围软组织的口腔癌的发展可能导致早期种植体丢失,并对患者的生活质量产生负面影响。口腔鳞状细胞癌是头颈部肿瘤中最常见的恶性肿瘤。在50岁以上的男性以及吸烟和/或酗酒者中发病率较高。不幸的是,口腔癌通常在晚期才被发现,此时治疗选择有限。因此,OSCC通常预后较差。尽管近年来对口腔癌变的了解有所进展,但种植体与周围恶性病变之间的关系尚不完全清楚。有人认为,钛腐蚀发生在牙种植体的顶部导致金属离子的释放。这些离子可能导致口腔上皮基因损伤,使正常黏膜更容易发生恶性转化。本章的目的是回顾临床特点,诊断和可能的致癌机制涉及种植牙周围口腔癌。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Oral Cancer around Dental Implants: Are the Clinical Manifestations and the Oncogenic Mechanisms Unique?
Osseointegrated implants have been an optimal treatment option for dental rehabilitation of fully or partially edentulous patients. Although peri-implantitis remains as the most common local risk factor for dental implant failure, the development of oral cancer involving the soft tissue around the titanium may lead to early implants loss and impact the quality of life of the patient negatively. Oral squamous cell carcinoma (OSCC) is the most common malignancy among head and neck tumors. It has higher prevalence in men over 50 years old, and in tobacco and/or alcohol users. Unfortunately, oral cancer is often detected in advanced stages, when the treatment options are limited. Thus, OSCC typically has poor prognosis. Despite the recent advances in oral carcinogenesis understanding, the relationship between dental implants and the development of malignant lesions around them is not completely understood. It has been suggested that the titanium corrosion occurring at the top of dental implants causes the release of metal ions. These ions might lead to oral epithelial genetic damage and higher susceptibility of normal mucosa to malignant transformation. The aim of this chapter was to review the clinical characteristics, diagnosis, and the possible carcinogenic mechanisms involved in oral cancer around dental implants.
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