肺立体定向放射治疗患者模拟过程中连续4D-CT扫描的评估

IF 0.7 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
M. Savanović, B. Štrbac, D. Jaroš, J. Foulquier
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引用次数: 1

摘要

目的:评估肺立体定向放射治疗(SBRT)模拟过程中连续四维计算机断层扫描(4D-CT)的呼吸幅度、肿瘤运动、患者体位和治疗量。材料与方法:对55例肺癌患者进行连续4D-CT扫描,每隔一周扫描一次,评估其呼吸幅度的变化和形状、患者体位和治疗量。研究了20例患者呼吸幅度变化对肺肿瘤运动的影响。从自由呼吸CT扫描和呼吸周期的10个阶段绘制总肿瘤体积(GTV),用于两种4d -CT(共440期)。结果:20例患者呼吸幅值下降3.6 (3.4 ~ 4.9)mm,肿瘤运动3.2 (0.4 ~ 5.0)mm,呼吸周期增加4 (2 ~ 6)s。在55例患者中,比较不规则呼吸模式和规则呼吸模式,扫描内呼吸振幅的变化是正常呼吸模式的4倍,呼吸周期的变化是正常呼吸模式的5倍,呼吸周期的变化是正常呼吸模式的8倍。使用指导时,呼吸幅度增加3 ~ 8mm,呼吸周期2 ~ 6s。在连续扫描之间,轮廓治疗量的差异小于10%。患者体位保持稳定,扫描间差异较小,仅为1.1 (0.6-1.4)mm。结论:降低扫描间呼吸幅值可减少肿瘤运动。当呼吸幅度减小时,扫描间和扫描内的呼吸周期增加,尤其是在不规则呼吸时。训练改善呼吸,保持呼吸振幅的初始形状。通过连续扫描可重现轮廓治疗量和患者体位。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The assessment of consecutive 4D-CT scans during simulation for lung stereotactic body radiation therapy patients
Abstract Purpose: To evaluate the breathing amplitude, tumor motion, patient positioning, and treatment volumes among consecutive four-dimensional computed tomography (4D-CT) scans, during the simulation for lung stereotactic body radiation therapy (SBRT). Material and methods: The variation and shape of the breathing amplitude, patient positioning, and treatment volumes were evaluated for 55 lung cancer patients after consecutive 4D-CT acquisitions, scanned at one-week intervals. The impact of variation in the breathing amplitude on lung tumor motion was determined for 20 patients. The gross tumor volume (GTV) was contoured from a free-breathing CT scan and at ten phases of the respiratory cycle, for both 4D-CTs (440 phases in total). Results: Breathing amplitude decreased by 3.6 (3.4-4.9) mm, tumor motion by 3.2 (0.4-5.0) mm while breathing period increased by 4 (2-6) s, inter-scan for 20 patients. Intra-scan variation was 4 times greater for the breathing amplitude, 5 times for the breathing period, and 8 times for the breathing cycle, comparing irregular versus regular breathing patterns for 55 patients. Using coaching, the breathing amplitude increases 3 to 8 mm, and the breathing period 2 to 6 s. Differences in the contoured treatment volumes were less than 10% between consecutive scans. Patient positioning remained stable, with a small inter-scan difference of 1.1 (0.6-1.4) mm. Conclusion: Decreasing the inter-scan breathing amplitude decreases the tumor motion reciprocally. When the breathing amplitude decreases, the breathing period increases at inter- and intra-scan, especially during irregular breathing. Coaching improves respiration, keeping the initial shape of the breathing amplitude. Contoured treatment volumes and patient positioning were reproducible through successive scans.
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来源期刊
Polish Journal of Medical Physics and Engineering
Polish Journal of Medical Physics and Engineering RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
1.30
自引率
0.00%
发文量
19
期刊介绍: Polish Journal of Medical Physics and Engineering (PJMPE) (Online ISSN: 1898-0309; Print ISSN: 1425-4689) is an official publication of the Polish Society of Medical Physics. It is a peer-reviewed, open access scientific journal with no publication fees. The issues are published quarterly online. The Journal publishes original contribution in medical physics and biomedical engineering.
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