2型糖尿病患者膳食胆固醇摄入量与致命性心血管事件风险的关系

IF 0.7 Q4 ENDOCRINOLOGY & METABOLISM
Diabetes Mellitus Pub Date : 2023-07-05 DOI:10.14341/dm12940
© А.К. Кунцевич, О. Д. Рымар, С.В. Мустафина, Г. И. Симонова, Л. В. Щербакова, Е.Г. Веревкин, А.О. Щетинина, С.К. Малютина, A. K. Kuntsevich, O. Rymar, S. Mustafina, G. Simonova, L. Shcherbakova, Evgeny G. Verevkin, A. O. Shchetinina, S. Malyutina
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引用次数: 0

摘要

背景:营养是影响人群健康的因素之一。饮食中的营养成分之一是膳食胆固醇,它来自肉制品和鸡蛋。迄今为止,关于胆固醇摄入与心血管疾病风险之间是否存在关系尚无明确的答案,这决定了对这一问题进行研究的相关性。目的:研究膳食胆固醇与2型糖尿病(DM2)患者心血管疾病(CVD)致死风险的关系。材料和方法:基线研究是在2003-2005年的hapie项目框架内进行的。包括DM2患者在内的队列观察时间为2003- 2005年至2018年12月31日,平均年龄为12.8岁,男女平均年龄为58.1±6.6岁。有关实际营养的数据来自一项对678名参与者的调查,该调查使用了一份问卷来评估食物摄入的频率,其中包括147种产品的信息。统计数据处理采用SPSS v.13.0软件包。为了比较独立的成对变量组,使用非参数Mann-Whitney U检验。采用Cox回归估计风险比(HR)。p<0.05为差异有统计学意义的临界水平。结果:研究发现,在患有DM2的个体中,与对照组相比,膳食胆固醇摄入量每1000千卡的最大分位数中心血管疾病致死的风险增加了56% (p=0.009)。一项对饮食中每1000千卡食用鸡蛋的分析显示,心血管疾病死亡风险增加52% (p=0.003)。每1000千卡食用肉制品与心血管疾病死亡风险无关(p = 0.361)。结论:在有DM2病史的新西伯利亚居民调查队列中,高膳食胆固醇水平(最高为505 mg/天)与心血管疾病死亡风险增加显著相关。这项研究的结果可能表明,高胆固醇食物可能与2型糖尿病患者死亡风险增加有关,这表明糖尿病患者需要控制他们的饮食胆固醇水平,并为这一人群提供更理想的饮食类型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association of dietary cholesterol intake with the risk of fatal cardiovascular events in individuals with type 2 diabetes
BACKGROUND: Nutrition is one of the factors affecting the health of a population. One of the nutritional components in the diet is dietary cholesterol, which comes from meat products and eggs. To date, there is no unequivocal answer about the presence of a relationship between cholesterol consumption and the risk of cardiovascular diseases, which determines the relevance of the study of this issue.AIM: To study the association of dietary cholesterol with the risk of fatal outcomes from cardiovascular disease (CVD) in individuals with type 2 diabetes mellitus (DM2).MATERIALS AND METHODS: The baseline study was carried out within the framework of the HAPIEE project in 2003-2005. The period of observation of the cohort, incl. for persons with DM2 lasted from 2003- 2005 to December 31, 2018 and averaged 12.8 years, the average age for both sexes was 58.1±6.6 years. Data on actual nutrition were obtained from a survey of 678 participants using a questionnaire to assess the frequency of food intake and included information on 147 products. Statistical data processing was carried out using the SPSS v.13.0 application package. To compare independent paired groups of variables, the nonparametric Mann-Whitney U test was used. The risk ratio (HR) was estimated using Cox regression. The critical level of statistical significance of differences was taken at p<0.05.RESULTS: It was found that in individuals with DM2, the risk of a fatal outcome from CVD in the maximum tertile of dietary cholesterol intake/1000 kcal increased by 56% compared with controls (p=0.009). An analysis of the consumption of chicken eggs/1000 kcal in the diet showed an increase in the risk of death from CVD in the maximum tertile of by 52% (p=0.003). Consumption of meat products/1000 kcal was not associated with the risk of death from CVD (p = 0.361).CONCLUSION: In the surveyed cohort of Novosibirsk residents with a history of DM2, high dietary cholesterol levels (505 mg/day in the maximum tertile) in the diet were significantly associated with an increased risk of death from CVD. The results of this study may suggest a possible association of high-cholesterol foods with an increased risk of death in people with type 2 diabetes, pointing to the need for people with diabetes to control their dietary cholesterol levels and more optimal type of diet for this population.
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来源期刊
Diabetes Mellitus
Diabetes Mellitus ENDOCRINOLOGY & METABOLISM-
CiteScore
1.90
自引率
40.00%
发文量
61
审稿时长
7 weeks
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