Comparison of postoperative pain relief by using intrathecal midazolam added to bupivacaine and buprenorphine

Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage. Inadequate pain control, apart from being inhumane, may result in increased morbidity or mortality. Aims and Objectives: To study the postoperative pain relief by intrathecal midazolam added to bupivacaine and buprenorphine. Methodology: This was a cross-sectional double-blinded comparative study carried out at our institute. The patients of age between 18 to 60 yrs. with ASA I and ASA II to be posted for surgery under spinal anaesthesia were enrolled to either Group A or B. Group A (n=45) patients received 15 mg hyperbaric bupivacaine and 75 mcg. Buprenorphine or Group B: (n=45) who received 15 mg hyperbaric bupivacaine and 75 mcg buprenorphine with additional Inj. Midazolam 2 mg (0.4 ml). The data was entered to excel sheets and analysed unpaired t-test, chi-square test calculated by SPSS 19 version software. Result: We observed that the demographic data was comparable. The duration of post-operative analgesia was significantly higher in Group B as compared to Group A i.e.11.18 ± 2.31 hrs. And 8.67± 3.27 hrs respectively. The VAS score at 10 hours post operatively was significantly lesser in the Group B as compared to Group A i.e. 4.23±1.94 and 6.93± 2.19 (t=6.19, df=88, p<0.001) respectively. Conclusion: The addition of midazolam to bupivacaine and buprenorphine significantly improved the post –operative analgesia.