内皮功能障碍将心血管疾病与儿童慢性肾脏疾病联系起来:一氧化氮缺乏的作用

Y. Tain
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引用次数: 8

摘要

心血管疾病(CVD)是儿童慢性肾脏疾病(CKD)患者死亡的主要原因。两种类型的传统和CKD相关的CVD危险因素在CKD儿童中普遍存在。许多这些因素与内皮功能障碍(ED)和一氧化氮(NO)缺乏有关。无缺陷ED既是CKD的原因,也是CKD的结果。因此,ED将CVD与儿童CKD联系起来,因为ED在CVD的发展中起着重要作用。这篇综述讨论了CVD的危险因素如何导致ED和NO缺乏,从而导致儿童CKD的CVD。通过新的无创方法早期发现ED,通过不同的治疗方法恢复NO的生物利用度,可以降低儿童CKD患者CVD的发病率和死亡率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Endothelial dysfunction links cardiovascular disease to pediatric chronic kidney disease: the role of nitric oxide deficiency.
Cardiovascular disease (CVD) is a major cause of death in pediatric patients with chronic kidney disease (CKD). Both types of traditional and CKD-related risk factors for CVD are prevalent in children with CKD. Many of these factors are associated with endothelial dysfunction (ED) and nitric oxide (NO) deficiency. ED with NO deficiency is both a cause and consequence of CKD. Hence, ED links CVD to pediatric CKD because ED plays a major role in the development of CVD. This review discusses how the risk factors for CVD contribute to ED and NO deficiency, leading to CVD in pediatric CKD. With early detection of ED by new non-invasive methods and restoration of NO bioavailability through different therapeutic approaches, the morbidity and mortality of CVD in pediatric CKD patients can be reduced.
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