体外循环对SARS-CoV2疫苗接种后免疫球蛋白G抗体效价的影响

IF 1.6 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Ryosuke Hayashi, Y. Takami, H. Fujigaki, Kentaro Amano, Yusuke Sakurai, Kiyotoshi Akita, Koji Yamana, A. Maekawa, Kuniaki Saito, Y. Takagi
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RESULTS Enrolled 63 study patients were divided into 39 undergoing surgery with CPB (Group CPB) and 24 without CPB (Group None). Preoperative vaccines were BNT162b2 (Pfizer/BioNTech) (n = 58, 92%) and mRNA-1273 (Moderna) (n = 5, 8%). While immunoglobulin G against the receptor-binding domain titres did not significantly decrease after surgery in Group None, they decreased significantly in Group CPB from 21.80 [11.15, 37.85] to 11.95 [6.80, 18.18] U/ml (P < 0.001) a day after surgery, 11.40 [7.85, 22.65] U/ml (P < 0.001) 14 days after surgery and 7.60 [4.80, 17.60] U/ml (P < 0.001) a month after surgery. The APRs a day after the surgery were significantly lower in Group CPB (0.46 [0.41, 0.60]) than in Group None (0.80 [0.68, 0.87]) (P < 0.001). CONCLUSIONS The SARS-CoV2 antibody titres significantly decreased with lower APRs immediately after surgery under CPB. 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引用次数: 1

摘要

【摘要】目的心血管疾病患者易感染严重急性呼吸综合征冠状病毒2 (SARS-CoV2)。虽然SARS-CoV2疫苗接种可能有效,但其对外科患者的影响尚未得到很好的研究。我们研究了心血管手术,特别是体外循环(CPB)对SARS-CoV2疫苗接种后抗体效价的影响。方法:对2021年7月至11月接受手术的患者进行前瞻性观察研究。测定受体结合域免疫球蛋白G水平,比较围手术期滴度计算抗体保存率(APR)。结果入组63例患者分为行CPB手术39例(CPB组)和未行CPB手术24例(无CPB组)。术前疫苗为BNT162b2(辉瑞/BioNTech) (n = 58, 92%)和mRNA-1273 (Moderna) (n = 5, 8%)。无组术后抗受体结合结构域免疫球蛋白G滴度无明显下降,CPB组术后1天21.80 [11.15,37.85]~ 11.95 [6.80,18.18]U/ml (P < 0.001),术后14天11.40 [7.85,22.65]U/ml (P < 0.001),术后1个月7.60 [4.80,17.60]U/ml (P < 0.001), CPB组明显下降。CPB组术后1 d APRs(0.46[0.41, 0.60])明显低于无CPB组(0.80 [0.68,0.87])(P < 0.001)。结论CPB术后即刻SARS-CoV2抗体滴度显著降低,APRs降低。根据我们的信息结果,CPB下的手术可能需要仔细考虑疫苗接种计划。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of cardiopulmonary bypass on immunoglobulin G antibody titres after SARS-CoV2 vaccination
Abstract OBJECTIVES Patients with cardiovascular disease are vulnerable to severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection. Although SARS-CoV2 vaccination may be effective, its impact on surgical patients is not well studied. We investigated the effects of cardiovascular surgery, especially under cardiopulmonary bypass (CPB), on the antibody titres after SARS-CoV2 vaccination. METHODS A prospective observational study was designed for patients undergoing surgery between July and November 2021. The immunoglobulin G against the receptor-binding domain was measured and antibody preserved rate (APR) was calculated from perioperative titres comparison. RESULTS Enrolled 63 study patients were divided into 39 undergoing surgery with CPB (Group CPB) and 24 without CPB (Group None). Preoperative vaccines were BNT162b2 (Pfizer/BioNTech) (n = 58, 92%) and mRNA-1273 (Moderna) (n = 5, 8%). While immunoglobulin G against the receptor-binding domain titres did not significantly decrease after surgery in Group None, they decreased significantly in Group CPB from 21.80 [11.15, 37.85] to 11.95 [6.80, 18.18] U/ml (P < 0.001) a day after surgery, 11.40 [7.85, 22.65] U/ml (P < 0.001) 14 days after surgery and 7.60 [4.80, 17.60] U/ml (P < 0.001) a month after surgery. The APRs a day after the surgery were significantly lower in Group CPB (0.46 [0.41, 0.60]) than in Group None (0.80 [0.68, 0.87]) (P < 0.001). CONCLUSIONS The SARS-CoV2 antibody titres significantly decreased with lower APRs immediately after surgery under CPB. Based on our informative results, careful considerations of vaccination schedule might be required for surgery under CPB.
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来源期刊
Interactive cardiovascular and thoracic surgery
Interactive cardiovascular and thoracic surgery CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
3.30
自引率
0.00%
发文量
292
审稿时长
2-4 weeks
期刊介绍: Interactive CardioVascular and Thoracic Surgery (ICVTS) publishes scientific contributions in the field of cardiovascular and thoracic surgery, covering all aspects of surgery of the heart, vessels and the chest. The journal publishes a range of article types including: Best Evidence Topics; Brief Communications; Case Reports; Original Articles; State-of-the-Art; Work in Progress Report.
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