SPECIES SPECTRUM OF NON-POLIOMYELITIC ENTEROVIRUSES IN KHMAO-YUGRA IN THE PRE-PANDEMIC AND POST-PANDEMIC PERIOD

Justification. Characteristics of regional features of the etiological structure of non-polio enterovirus infection in the pre-pandemic and post-pandemic periods. Goal. Assessment of monitoring of the etiological structure of non-polio entero-viral infection in the pre-pandemic and post-pandemic periods. Materials and methods. The data from the forms of statistical observation for 2013-2022 and the results of molecular genetic studies of the structure of non-polio enterovirus infection in the pre-pandemic and post-pandemic periods were used. Results. It was found that the dynamics of the incidence of EVI in the Khanty-Mansi Autonomous Okrug in the pre-pandemic period for COVID-19 is characterized by a high level of activity of the epidemic process, exceeding the average for the Russian Federation by 5-6 times. The predominant share in the total incidence of EVI is the urban population with a predominance of children under 6 years of age. During the period of the highest incidence rates in 2017 and 2019, Coxsackie A6 viruses in combination with ECHO30, Coxsackie A9 dominated, and during the period of their decline, the proportion of EV A71, Coxsackie A16 increased. In the post-pandemic period, the calculated trends of dynamics for 2022 were confirmed for the dominant viruses and enterovirus A71. In the same year, there was an increase in the identification of Coxsackie B2 and ECHO6 viruses, which previously circulated irregularly and in isolated cases. The prevalence of CV-A6 in the epidemic process was accompanied by clinical manifestations of infection mainly in the form of enterovirus vesicular stomatitis, and with a high frequency of ECHO30, computer cases were recorded in most cases. Conclusion. Based on the results of monitoring of the etiological structure of non-poliomyelitis enterovirus infection in the pre-pandemic period, a trend towards a further increase in the incidence of EVI in the Khanty-Mansi Autonomous Okrug is predicted. Genotyping of the detected strains makes it possible to determine the spectrum of enterovirus strains endemic to the territory and predict their prevalence, which is necessary to prevent the spread of EVI and ensure sanitary and epidemiological well-being in the region.