J. Bellot, M. Palmero, C. García-Cabanes, M. Sanz, A. Orts
{"title":"缺氧应激对rpe细胞的影响:抗氧化处理的影响","authors":"J. Bellot, M. Palmero, C. García-Cabanes, M. Sanz, A. Orts","doi":"10.1081/CUS-100000338","DOIUrl":null,"url":null,"abstract":"Retinal pigmented epithelium (RPE) is an ocular tissue that performs several important functions such as light perception and phagocytosis. This study investigated the effects of hypoxia and serum and glucose deprivation of the RPE tissue. The possible protective effects of antioxidants were also studied by determining cell viability, ATP content, and DNA fragmentation. The results demonstrate that antioxidants can protect RPE tissue from death through the inhibition of some mechanisms that lead to cellular apoptosis.","PeriodicalId":17547,"journal":{"name":"Journal of Toxicology-cutaneous and Ocular Toxicology","volume":"173 1","pages":"29 - 38"},"PeriodicalIF":0.0000,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"EFFECT OF HYPOXIC STRESS IN RPE CELLS: INFLUENCE OF ANTIOXIDANT TREATMENTS\",\"authors\":\"J. Bellot, M. Palmero, C. García-Cabanes, M. Sanz, A. Orts\",\"doi\":\"10.1081/CUS-100000338\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Retinal pigmented epithelium (RPE) is an ocular tissue that performs several important functions such as light perception and phagocytosis. This study investigated the effects of hypoxia and serum and glucose deprivation of the RPE tissue. The possible protective effects of antioxidants were also studied by determining cell viability, ATP content, and DNA fragmentation. The results demonstrate that antioxidants can protect RPE tissue from death through the inhibition of some mechanisms that lead to cellular apoptosis.\",\"PeriodicalId\":17547,\"journal\":{\"name\":\"Journal of Toxicology-cutaneous and Ocular Toxicology\",\"volume\":\"173 1\",\"pages\":\"29 - 38\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2001-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Toxicology-cutaneous and Ocular Toxicology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1081/CUS-100000338\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Toxicology-cutaneous and Ocular Toxicology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1081/CUS-100000338","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
EFFECT OF HYPOXIC STRESS IN RPE CELLS: INFLUENCE OF ANTIOXIDANT TREATMENTS
Retinal pigmented epithelium (RPE) is an ocular tissue that performs several important functions such as light perception and phagocytosis. This study investigated the effects of hypoxia and serum and glucose deprivation of the RPE tissue. The possible protective effects of antioxidants were also studied by determining cell viability, ATP content, and DNA fragmentation. The results demonstrate that antioxidants can protect RPE tissue from death through the inhibition of some mechanisms that lead to cellular apoptosis.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
