Synergic fabrication of hybrid nanocapsules gold-organosilica for MRI-guided photothermal-enhanced synergistic effect chemodynamic lung cancer therapy

Abstract In contrast to the typical template-based multistep approach for constructing multi-functional mesoporous hollow silica nanocomposites (MHSN), a simple and template-free fabricate system has been developed to develop versatile mesoporous hollow silica nanocapsules (OSNs) encompassing together isopentyl acetate (IsA) solution and AuNPs. This new material has tiny and homogeneous particle sizes (∼82 nm), a large surface area (535 m2 g−1), and remarkable colloidal durability in water. The oil-phase IsA with high volatility and a low boiling point (142 °C) is critical in building bulky hollow cavities from structural strategy. It allows the IsA@OSNs to become an effective development mediator in the ablation of high-intensity focused ultrasound (HIFU) treatment. Furthermore, the distinctive satellite-like dispersion of Gold (AuNPs) on the silica shell provided IsA@OSNs with outstanding magnetic resonance imaging (MRI) contrasts in A549 lung cells in vitro and in vivo. Furthermore, such unique theranostics agents have excellent systemic toxicity, which promises well for promising clinical use in MRI-piloted HIFU treatment. Graphical Abstract