Fatemeh Mehradnia, Cara Moloney, R. Cavanagh, A. Pearce, A. Ritchie, P. Clarke, R. Rahman, Asmaa Ibrahim, Anna M. Grabowskab, C. Alexander
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Histopathological impact of Redox-responsive methacrylamide based micellar nanoparticles on Orthotopic Models of Triple Negative Breast Cancers
The therapeutic efficacy of anticancer nanocarriers ishighly dependent on their size, shape, targeting ability, andstimuli-responsiveness. Herein, we studied the in vivo therapeutic efficacy ofDoxorubicin (Dox) loaded redox responsive micellar-like nanoparticles (MNPs)based on linear 2-hydroxypropyl methacrylamide (HPMA) via histopathologicalevaluations. The therapeutic efficacy of DOX-loaded micellar-like Nanoparticlessignificantly improved while the side effects reduced as confirmed byhistopathological examinations. H&E and tunnel staining of tumor tissuesindicated the higher population of apoptotic tumor cells in both treatmentgroups containing DOX. These redox responsive crosslinked HPMA-basedmicellar-like nanoparticles with acceptable therapeutic efficacy and apoptosisinduction in cancerous cells proved to be promising nanomedicine for breast cancer chemotherapy.
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