氧化还原反应性甲基丙烯酰胺胶束纳米颗粒对三阴性乳腺癌原位模型的组织病理学影响

Fatemeh Mehradnia, Cara Moloney, R. Cavanagh, A. Pearce, A. Ritchie, P. Clarke, R. Rahman, Asmaa Ibrahim, Anna M. Grabowskab, C. Alexander
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引用次数: 0

摘要

抗癌纳米载体的治疗效果高度依赖于它们的大小、形状、靶向能力和刺激反应性。在此,我们通过组织病理学评估,研究了基于线性2-羟丙基甲基丙烯酰胺(HPMA)的负载氧化还原反应胶束样纳米颗粒(MNPs)的阿霉素(Dox)在体内的治疗效果。经组织病理学检查证实,载dox胶束状纳米颗粒的治疗效果明显提高,副作用减少。肿瘤组织H&E和隧道染色显示,两组均有较高的肿瘤细胞凋亡。这些氧化还原反应交联的基于hpma的胶束样纳米颗粒具有可接受的治疗效果和癌细胞凋亡诱导,被证明是有前途的乳腺癌化疗纳米药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Histopathological impact of Redox-responsive methacrylamide based micellar nanoparticles on Orthotopic Models of Triple Negative Breast Cancers
The therapeutic efficacy of anticancer nanocarriers ishighly dependent on their size, shape, targeting ability, andstimuli-responsiveness. Herein, we studied the in vivo therapeutic efficacy ofDoxorubicin (Dox) loaded redox responsive micellar-like nanoparticles (MNPs)based on linear 2-hydroxypropyl methacrylamide (HPMA) via histopathologicalevaluations. The therapeutic efficacy of DOX-loaded micellar-like Nanoparticlessignificantly improved while the side effects reduced as confirmed byhistopathological examinations. H&E and tunnel staining of tumor tissuesindicated the higher population of apoptotic tumor cells in both treatmentgroups containing DOX. These redox responsive crosslinked HPMA-basedmicellar-like nanoparticles with acceptable therapeutic efficacy and apoptosisinduction in cancerous cells proved to be promising nanomedicine for breast cancer chemotherapy.
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