组蛋白甲基转移酶Nsd2是滤泡辅助性T细胞分化所必需的

The Tokushima journal of experimental medicine Pub Date : 2019-10-21 DOI:10.1084/jem.20190832

Xuehui Long, Le Zhang, Yang Zhang, Min Min, Bichun Lin, Jingjing Chen, Xiaojie Ma, Sulan Zhai, Zhenming Cai, Yingxia Liu, Yanlai Lu, N. Che, W. Tan, J. Qin, Xiaoming Wang

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引用次数: 16

摘要

在滤泡辅助性T细胞分化过程中Bcl6表达的调控尚不完全清楚。在这里，Long等人发现T细胞激活诱导H3K36me2甲基转移酶Nsd2，以CD28和icos依赖的方式，促进Bcl6表达和Tfh分化。

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Histone methyltransferase Nsd2 is required for follicular helper T cell differentiation

Regulation of Bcl6 expression during follicular helper T cell differentiation remains incompletely understood. Here, Long et al. show that T cell activation induces H3K36me2 methyltransferase Nsd2, in a CD28- and ICOS-dependent manner, to promote Bcl6 expression and Tfh differentiation.

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The Tokushima journal of experimental medicine

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