COVID-19无症状低氧血症的流行、表现和结局

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-01-01 DOI:10.1177/11795484221082761

Amélia Ribeiro, M. Mendonça, C. Sabina Sousa, M. Trigueiro Barbosa, M. Morais‐Almeida

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引用次数: 3

摘要

据报道，少数感染2019冠状病毒病(COVID-19)的患者存在呼吸困难。即使是肺炎患者也会出现低氧血症而没有任何呼吸窘迫，这种现象被称为“沉默”或“快乐低氧血症”。在目前的大流行期间，仅对这一主题进行了几项研究，而且这些研究相当不同。因此，“隐性低氧血症”的患病率差异很大。虽然研究没有明确显示“沉默性低氧血症”与以呼吸困难为表现的低氧血症相比有更差的预后倾向，但一些研究表明，“沉默性低氧血症”患者也不能避免不良预后。为了更好地指导临床医生和研究者，有必要对“隐性低氧血症”进行统一的定义。需要更多的研究来阐明“隐性低氧血症”的机制，以及它在疾病进展和结局中的表现和影响，以便更好地协助医生护理COVID-19患者。

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Prevalence, Presentation and Outcomes of Silent Hypoxemia in COVID-19

Dyspnea is reported in a minority of patients affected by coronavirus disease 2019 (COVID-19). Even patients with pneumonia can present hypoxemia without any respiratory distress, a phenomenon known as “silent” or “happy hypoxemia”. During the current pandemic there were only a few studies conducted on this subject and these were quite heterogeneous. Therefore, the prevalence of “silent hypoxemia” varied substantially. While studies did not show a clear tendency of “silent hypoxemia” to poorer outcomes compared to hypoxemia presenting with dyspnea, several showed that patients with “silent hypoxemia” are not protected from poor outcomes either. There is a need for a uniform definition of “silent hypoxemia”, in order to better guide clinicians and investigators. More studies are needed to shed light on the mechanisms of “silent hypoxemia”, as well as its presentation and influence in the disease's progression and outcomes, so as to better assist physicians in the care of COVID-19 patients.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.