过敏原免疫治疗老年变应性鼻炎患者HDM的远期疗效。

Andrzej Bożek, Agnieszka Bogacz-Piaseczyńska, Martyna Miodońska, Dominika Sadowska
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引用次数: 0

摘要

简介:过敏原免疫疗法(AIT)是一种有效的治疗变应性鼻炎,可能有长期的好处。然而,这些福利并没有严格规定给老年人。目的:评价AIT对60岁以上变应性鼻炎和屋尘螨(HDM)过敏患者7年的治疗效果。材料与方法:观察HDM-AIT治疗3年后的患者,评估治疗的持续临床效果。在舌下(SLIT)和注射AIT (SCIT)后监测7年的平均调整症状评分(AAdSS)和sIgG4。结果:HDM-AIT治疗3年后,基于AAdSS的SLIT组和SCIT组与基线组和安慰剂组比较,临床疗效显著(p < 0.05)。经过7年的随访,与安慰剂相比,脱敏患者的临床症状有持续下降的趋势。所有脱敏患者血清sIgG4均持续存在。结论:AIT对老年人变应性鼻炎和屋尘螨过敏有一定的治疗作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Long-term benefit after allergen immunotherapy to HDM in elderly patients with allergic rhinitis.

Introduction: Allergen immunotherapy (AIT) is an effective therapy for allergic rhinitis and may have long-term benefits. However, these benefits have not been strictly defined for older people.

Aim: The evaluation of the effectiveness of AIT in patients over 60 with allergic rhinitis and house dust mites (HDM) allergy over a period of 7 years was performed.

Material and methods: Patients after three years of HDM-AIT were observed to assess the sustained clinical effect of treatment. The average adjusted symptom score (AAdSS) and sIgG4 were monitored for 7 years after sublingual (SLIT) and injection AIT (SCIT).

Results: After 3 years of HDM-AIT, a significant clinical effect was observed in the group after SLIT and SCIT based on AAdSS compared to the baseline and the placebo group (p < 0.05). After 7 years of follow-up, there was a sustained trend of decrease in clinical symptoms in desensitized patients relative to placebo. Serum sIgG4 was constantly present in all desensitized patients.

Conclusions: AIT may be beneficial for treating seniors with allergic rhinitis and allergies to house dust mites.

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