{"title":"东北汉族抵抗素-420C/G多态性与2型糖尿病大血管病变的相关性分析","authors":"M. Yan","doi":"10.4236/JBM.2017.512003","DOIUrl":null,"url":null,"abstract":"Objective To study the allelic and genotypic frequence distribution of RETN-420C/G single nucleotide polymorphisms(SNPs) and its relationship with type 2 diabetes mellitus(T2DM) complicated with macroangiopathy in Han population of northeast China.Methods The genotypes and their frequencies of a total of 180 cases,including 60 cases of T2DM complicated with macroangiopathy,60 cases of simple T2DM and 60 cases of normal control(ND),were measured by PCR-RFLP.Results The allelic frequencies and simple CC/GC+GG genotype in T2DM complicated with macroangiopathy group were significant different compared with ND group(P0.01).The allelic frequencies and CC/GC+GG genotype in T2DM comlicated with macroangiopathy group were significant different compared with T2DM group(P0.05).The GC+GG genotype in T2DM complicated with macroangiopathy group was significantly higher than that in T2DM group(P0.05).Conclusion The RETN-420C/G polymorphism has a correlation with the occurrence of T2DM complicated with macroangiopathy in Han population of northeast China.","PeriodicalId":16277,"journal":{"name":"Journal of Jilin University","volume":"30 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2017-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Analysis on correlation between resistin -420C/G polymorphism and type 2 diabetes mellitus macroangiopathy in Han population of northeast China\",\"authors\":\"M. Yan\",\"doi\":\"10.4236/JBM.2017.512003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective To study the allelic and genotypic frequence distribution of RETN-420C/G single nucleotide polymorphisms(SNPs) and its relationship with type 2 diabetes mellitus(T2DM) complicated with macroangiopathy in Han population of northeast China.Methods The genotypes and their frequencies of a total of 180 cases,including 60 cases of T2DM complicated with macroangiopathy,60 cases of simple T2DM and 60 cases of normal control(ND),were measured by PCR-RFLP.Results The allelic frequencies and simple CC/GC+GG genotype in T2DM complicated with macroangiopathy group were significant different compared with ND group(P0.01).The allelic frequencies and CC/GC+GG genotype in T2DM comlicated with macroangiopathy group were significant different compared with T2DM group(P0.05).The GC+GG genotype in T2DM complicated with macroangiopathy group was significantly higher than that in T2DM group(P0.05).Conclusion The RETN-420C/G polymorphism has a correlation with the occurrence of T2DM complicated with macroangiopathy in Han population of northeast China.\",\"PeriodicalId\":16277,\"journal\":{\"name\":\"Journal of Jilin University\",\"volume\":\"30 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-11-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Jilin University\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4236/JBM.2017.512003\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Jilin University","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4236/JBM.2017.512003","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Analysis on correlation between resistin -420C/G polymorphism and type 2 diabetes mellitus macroangiopathy in Han population of northeast China
Objective To study the allelic and genotypic frequence distribution of RETN-420C/G single nucleotide polymorphisms(SNPs) and its relationship with type 2 diabetes mellitus(T2DM) complicated with macroangiopathy in Han population of northeast China.Methods The genotypes and their frequencies of a total of 180 cases,including 60 cases of T2DM complicated with macroangiopathy,60 cases of simple T2DM and 60 cases of normal control(ND),were measured by PCR-RFLP.Results The allelic frequencies and simple CC/GC+GG genotype in T2DM complicated with macroangiopathy group were significant different compared with ND group(P0.01).The allelic frequencies and CC/GC+GG genotype in T2DM comlicated with macroangiopathy group were significant different compared with T2DM group(P0.05).The GC+GG genotype in T2DM complicated with macroangiopathy group was significantly higher than that in T2DM group(P0.05).Conclusion The RETN-420C/G polymorphism has a correlation with the occurrence of T2DM complicated with macroangiopathy in Han population of northeast China.
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