巴比妥酸连接Isatin衍生物的合成及生物活性研究

Egyptian Academic Journal of Biological Sciences C Physiology and Molecular Biology Pub Date : 2023-06-19 DOI:10.21608/eajbsc.2023.307820

Mohammed Abdul Shahed, A. Mageed

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引用次数: 0

摘要

本研究主要通过两步法合成异辛-巴比妥酸化合物。第一步，利用曼尼希反应，通过与巴比妥酸和甲醛反应合成Isatin的新衍生物。该反应生成了isatin -巴比妥酸衍生物。第二步，这些Isatin衍生物与各种苯胺衍生物进一步反应，生成含有Isatin的新化合物。光谱方法包括FTIR, 1h NMR

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Synthesis and Biological Activity of Barbituric acid- linked Isatin Derivatives

The study focuses on the synthesis of isatin-barbituric acid compounds through a two-step process. In the first step, using mannich reaction, new derivatives of Isatin are synthesized by reacting Isatin with either barbituric acid, along with formaldehyde. This reaction results in the formation of Isatin-barbituric acid derivative. In the second step, these Isatin derivatives are further reacted with various aniline derivatives to generate new compounds containing Isatin. Spectroscopic methods including FTIR, 1 H NMR

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Egyptian Academic Journal of Biological Sciences C Physiology and Molecular Biology

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