生与死边缘的生物物理学:细胞凋亡机制的根本控制

Samantha J. Hack, Wendy S. Beane, K. Tseng
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引用次数: 2

摘要

最近的研究进一步加深了我们对死亡细胞和活细胞在不同生理环境下如何相互作用的理解,然而,启动和介导细胞凋亡和细胞凋亡诱导增殖的信号传导比以前认为的要复杂得多。一个日益重要的研究领域是细胞凋亡的生物物理控制。除了生化调节外,生物物理信号(包括氧化还原化学、生物电梯度、声和磁刺激)也是已知的但尚未充分研究的细胞死亡和凋亡诱导增殖的调节因子。越来越多的证据表明,生物物理信号可能是治疗干预的关键目标。这篇综述强调了已知的生物物理信号在细胞发育、再生和癌变过程中控制细胞死亡机制中的作用。由于生物物理信号可以在时空上控制,而无需基因操作,因此进一步的研究可能会导致对凋亡途径的微调调节,从而指导所需的治疗结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Biophysics at the edge of life and death: Radical control of apoptotic mechanisms
Recent studies have furthered our understanding of how dying and living cells interact in different physiological contexts, however the signaling that initiates and mediates apoptosis and apoptosis-induced proliferation are more complex than previously thought. One increasingly important area of study is the biophysical control of apoptosis. In addition to biochemical regulation, biophysical signals (including redox chemistry, bioelectric gradients, acoustic and magnetic stimuli) are also known yet understudied regulators of both cell death and apoptosis-induced proliferation. Mounting evidence suggests biophysical signals may be key targets for therapeutic interventions. This review highlights what is known about the role of biophysical signals in controlling cell death mechanisms during development, regeneration, and carcinogenesis. Since biophysical signals can be controlled spatiotemporally, bypassing the need for genetic manipulation, further investigation may lead to fine-tuned modulation of apoptotic pathways to direct desired therapeutic outcomes.
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