几种温度下溶剂混合物中阿托伐他汀钙的热力学分析

IF 1.2 4区化学 Q4 CHEMISTRY, PHYSICAL

Physics and Chemistry of Liquids Pub Date : 2023-05-24 DOI:10.1080/00319104.2023.2208255

M. Ariaeinia, E. Rahimpour, S. Mirzaeei, Anahita Fathi Azarbayjani, A. Jouyban

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引用次数: 0

摘要

共溶性是一种广泛使用的提高药物溶解度的方法。关于阿托伐他汀钙(ATC)溶解度的数据有限。本研究的目的是测定ATC在不同温度(293.15,298.15,303.15,308.15和313.15 K)下在甘油+水和2-丙醇+水混合物中的溶解度，计算ATC溶解过程的表观热力学性质，包括吉布斯自由能(ΔG°sol)、焓(ΔH°sol)和熵(ΔS°sol)。考察了ATC在不同浓度阴离子、阳离子和非离子表面活性剂中的溶解度。该药物最有效地溶解在十二烷基硫酸钠(SLS)中。t20未引起药物溶解度的增加。苯扎氯铵可能与ATC阴离子形成不溶性盐，导致药物溶解度降低。共溶性数据通过Jouyban-Acree和Jouyban-Acree - van 't Hoff方程进行相关性分析。

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Thermodynamic analysis of atorvastatin calcium in solvent mixtures at several temperatures

ABSTRACT Cosolvency is a widely used method employed to enhance drug solubility. There are limited data on the solubility of atorvastatin calcium (ATC). The aim of this work is to determine ATC solubility in glycerol + water and 2-propanol + water mixtures at several temperatures (293.15, 298.15, 303.15, 308.15 and 313.15 K). The apparent thermodynamic properties of the ATC dissolution process including Gibbs free energy (ΔG°sol), enthalpy (ΔH°sol) and entropy (ΔS°sol) were calculated. The ATC solubility in various concentrations of the anionic, cationic and non-ionic surfactant was explored. The drug is most efficiently dissolved in sodium lauryl sulphate (SLS). Tween 20 did not cause any increment in drug solubility. Benzalkonium chloride may form an insoluble salt with ATC anion resulting in a decrease in drug solubility. Cosolvency data were correlated by Jouyban–Acree and Jouyban–Acree–van’t Hoff equation.

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来源期刊

Physics and Chemistry of Liquids 化学-物理：凝聚态物理

CiteScore

3.30

自引率

8.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Physics and Chemistry of Liquids publishes experimental and theoretical papers, letters and reviews aimed at furthering the understanding of the liquid state. The coverage embraces the whole spectrum of liquids, from simple monatomic liquids and their mixtures, through charged liquids (e.g. ionic melts, liquid metals and their alloys, ions in aqueous solution, and metal-electrolyte systems) to molecular liquids of all kinds. It also covers quantum fluids and superfluids, such as Fermi and non-Fermi liquids, superconductors, Bose-Einstein condensates, correlated electron or spin assemblies. By publishing papers on physical aspects of the liquid state as well as those with a mainly chemical focus, Physics and Chemistry of Liquids provides a medium for the publication of interdisciplinary papers on liquids serving its broad international readership of physicists and chemists.