几种温度下溶剂混合物中阿托伐他汀钙的热力学分析

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-05-24 DOI:10.1080/00319104.2023.2208255

M. Ariaeinia, E. Rahimpour, S. Mirzaeei, Anahita Fathi Azarbayjani, A. Jouyban

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引用次数: 0

摘要

共溶性是一种广泛使用的提高药物溶解度的方法。关于阿托伐他汀钙(ATC)溶解度的数据有限。本研究的目的是测定ATC在不同温度(293.15,298.15,303.15,308.15和313.15 K)下在甘油+水和2-丙醇+水混合物中的溶解度，计算ATC溶解过程的表观热力学性质，包括吉布斯自由能(ΔG°sol)、焓(ΔH°sol)和熵(ΔS°sol)。考察了ATC在不同浓度阴离子、阳离子和非离子表面活性剂中的溶解度。该药物最有效地溶解在十二烷基硫酸钠(SLS)中。t20未引起药物溶解度的增加。苯扎氯铵可能与ATC阴离子形成不溶性盐，导致药物溶解度降低。共溶性数据通过Jouyban-Acree和Jouyban-Acree - van 't Hoff方程进行相关性分析。

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Thermodynamic analysis of atorvastatin calcium in solvent mixtures at several temperatures

ABSTRACT Cosolvency is a widely used method employed to enhance drug solubility. There are limited data on the solubility of atorvastatin calcium (ATC). The aim of this work is to determine ATC solubility in glycerol + water and 2-propanol + water mixtures at several temperatures (293.15, 298.15, 303.15, 308.15 and 313.15 K). The apparent thermodynamic properties of the ATC dissolution process including Gibbs free energy (ΔG°sol), enthalpy (ΔH°sol) and entropy (ΔS°sol) were calculated. The ATC solubility in various concentrations of the anionic, cationic and non-ionic surfactant was explored. The drug is most efficiently dissolved in sodium lauryl sulphate (SLS). Tween 20 did not cause any increment in drug solubility. Benzalkonium chloride may form an insoluble salt with ATC anion resulting in a decrease in drug solubility. Cosolvency data were correlated by Jouyban–Acree and Jouyban–Acree–van’t Hoff equation.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.