PD-1特异性构象抗体鉴定计算管道的开发。

Annals of the symposium: vaccines, biopharmaceuticals, in vitro diagnosis, management, other related themes Pub Date : 2022-01-01 DOI:10.35259/isi.2022_52283

G. Sartori, E. Gaieta, Victoria Moreira, Samuel Almeida, J. Sampaio

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引用次数: 0

摘要

在文学。最后，修饰抗体不能识别原抗原，因为虽然原抗体的正确位姿很容易被识别，但通过对接，突变抗体甚至不能产生晶体位姿。结论:在这里，我们描述并应用了一种新的方案来计算设计新的抗体，利用cdr环的结构可变性和低计算成本。

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Development of computational pipeline for antibody identification against specific conformations of PD-1.

in literature. Finally, the modified antibody does not recognize the original antigen, since while the original antibody had its correct pose readily identified, by docking, the mutated antibody not even generated the crystallographic pose. Conclusion: Here we described and applied a new protocol for computationally design new antibodies taking advantage of the structural variability of CDRs loops at low computational cost.

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Annals of the symposium: vaccines, biopharmaceuticals, in vitro diagnosis, management, other related themes

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