p -选择素在多发性骨髓瘤患者心血管事件预后中的价值

M. Panasenko, B. Samura, S. Dotsenko
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引用次数: 1

摘要

近几十年来,多发性骨髓瘤(MM)的生存率大大提高。MM通常在老年人中诊断。患者不一定死于MM,因此心血管健康可能是威胁长期生存的关键因素。该研究的目的是:评估循环p -选择素对完全或部分缓解的多发性骨髓瘤患者心血管事件的预后价值。材料和方法。97名完全或部分缓解的MM患者参加了这项研究。在入组前,没有患者接受过任何血脂调节药物,包括他汀类药物或贝特类药物。观察期长达1年。采集血液样本进行生物标志物测量。采用酶联免疫吸附法测定外周血p -选择素水平。观察期间有25例MM进展,5例因随访不良被排除。67例患者纳入统计分析。18例患者(26.9%)在随访期间发生36例累积临床事件,其分布如下:2例心血管死亡,16例心律失常,3例心脏缺血事件,1例中风,4例慢性心力衰竭,10例因心血管原因住院。2例死亡与心血管病理无关。无事件组和有心血管事件组p -选择素循环水平中位数分别为58.24 ng/ml(95%可信区间(CI) = 32.27 ~ 77.48 ng/ml)和87.57 ng/ml (95% CI = 51.12 ~ 114.89 ng/ml) (Р < 0.01)。在多变量logistic回归中,循环p -选择素独立预测累积心血管事件(优势比(OR) = 1.11;95% ci = 1.08-1.15;严重冠状病毒病(COVID-19)后1年观察期内患者的患病率为Р = 0.02。在多发性骨髓瘤缓解期患者中,循环p -选择素增加与累积心血管事件增加相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Value of P-selectin in the prognosis of cardiovascular events in patients with multiple myeloma
Multiple myeloma (MM) survival has greatly improved in recent decades. MM is usually diagnosed in elderlies. Patients do not necessarily die from MM, so cardiovascular health may be a key factor threatening long-term survival. The aim of the research: to evaluate the prognostic value of circulating P-selectin for cardiovascular events in patients with multiple myeloma in full or partial remission. Materials and methods. 97 patients with MM with complete or partial remission were enrolled in the study. None of the patients had received any lipid-modulating medications, including statins or fibrates, before enrollment. The observation period was up to 1 year. Blood samples for biomarkers measurements were collected. ELISA method for measurements of circulating level of P-selectin was used. Results. During the observation period progression of MM was proved in 25 patients, 5 persons were excluded for poor follow-up. 67 patients were included in the statistical analysis. Thirty-six cumulative clinical events occurred in 18 patients (26.9 %) within the follow-up, with their distribution being as follows: 2 cardiovascular deaths, 16 cardiac arrhythmias, 3 cardiac ischemic events, 1 stroke, 4 chronic heart failures, and 10 hospital admissions for cardiovascular reasons. 2 deaths were not related with cardiovascular pathology. Medians of circulating levels of P-selectin in free-events subject cohort and subjects cohort with cardiovascular events were 58.24 ng/ml (95 % confidence interval (CI) = 32.27–77.48 ng/ml) and 87.57 ng/ml (95 % CI = 51.12–114.89 ng/ml) (Р < 0.01). In multivariate logistic regression circulating P-selectin independently predicted cumulative cardiovascular events (odds ratio (OR) = 1.11; 95 % CI = 1.08–1.15; Р = 0.02) in patients after sever coronavirus disease (COVID-19) within 1 year of observation period. Conclusions. Among patients with documented multiple myeloma in remission increased circulating P-selectin was associated with increased cumulative cardiovascular events.
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