Fertility-sparing treatment of endometrial cancer

Endometrial cancer is one of the most common gynecologic cancers in Thailand. Approximately 15-25% of women are diagnosed during their premenopausal period. Standard treatment of endometrial cancer includes total abdominal hysterectomy and bilateral salpingo-oophorectomy with staging procedures. However, conservative management with progestin therapy may be considered in selected patients for fertility preservation. Candidates for fertility-sparing treatment are women with early stage, well differentiated endometrioid adenocarcinoma without myometrial invasion. Oncologic and fertility outcomes of patients treated with conservative management are limited. Therefore, close surveillance is needed during conservative management. Definitive treatment should be performed after completion of childbearing.