产前暴露于尼古丁损害了大鼠幼崽以年龄依赖的方式对缺氧的保护反应

James E Fewell, Francine G Smith, Vienna K.Y Ng
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引用次数: 85

摘要

本研究以大鼠幼鼠为实验对象,探讨出生前暴露于尼古丁与出生后年龄对促进缺氧环境下幼鼠生存的保护反应的相互作用。从妊娠第6天或第7天开始,怀孕大鼠通过28天渗透性微型泵连续接受尼古丁(每天每公斤体重约6毫克酒石酸尼古丁)或载药。在出生后1-2、5-6和10-11天,幼鼠暴露于缺氧气体混合物(97% N2和3% CO2)产生的单期缺氧中,并测定其最后一次喘息时间,或反复暴露于缺氧中,并测定其原发性呼吸暂停自动复苏的能力。产前暴露于尼古丁会缩短最后一次喘息的时间,但仅限于1 - 2天大的动物。然而,由于尼古丁对喘息模式的影响,这个年龄组的喘息次数有所增加。此外,产前暴露于尼古丁减少了1-2日龄和5 - 6日龄幼鼠的成功自我复苏次数,并影响了死亡前的心肺事件,但对10 - 11日龄幼鼠没有影响。因此,我们的实验表明,产前暴露于尼古丁损害了大鼠幼鼠的保护反应,这些反应可能以年龄依赖的方式在暴露于缺氧时维持生命。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prenatal exposure to nicotine impairs protective responses of rat pups to hypoxia in an age-dependent manner

Experiments were carried out on rat pups to investigate the interaction between prenatal exposure to nicotine and postnatal age on protective responses that promote survival during exposure to hypoxia. From days 6 or 7 of gestation, pregnant rats received either nicotine (∼6 mg of nicotine tartrate/kg of body weight per day) or vehicle continuously via a 28-day osmotic minipump. On postnatal days 1–2, 5–6 and 10–11, the pups were exposed either to a single period of hypoxia produced by breathing an anoxic gas mixture (97% N2 and 3% CO2) and their time to last gasp determined, or they were exposed repeatedly to hypoxia and their ability to autoresuscitate from primary apnea determined. Prenatal exposure to nicotine decreased the time to last gasp, but only in the 1–2-day-old animals. The total number of gasps was, however, increased in this age group due to the effect of nicotine on the gasping pattern. Furthermore, prenatal exposure to nicotine decreased the number of successful autoresuscitations and influenced the cardiorespiratory events preceding death in the 1–2- and 5–6-day-old pups but not in the 10–11-day-old pups. Thus, our experiments show that prenatal exposure to nicotine impairs protective responses of rat pups that may sustain life during exposure to hypoxia in an age-dependent manner.

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