大鼠苯丙氨酸羟化酶基因启动子序列分析

DNA Sequence Pub Date : 2001-01-01 DOI:10.3109/10425170109080774

Diane Rees, M. J. Fisher, I. McDowall

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引用次数: 1

摘要

我们已经鉴定了大鼠苯丙氨酸羟化酶(PAH)基因的5 '端(3218bp)。在这个多环芳烃启动子序列中，我们已经确定了一些类似于人类和小鼠多环芳烃启动子中存在的假定调控位点。特别是，已经确定了潜在的hnf1结合位点和CRE。这些序列分别结合大鼠核提取物中存在的HNF1和CREB转录因子，可能在PAH表达的组织特异性和激素控制中具有重要意义。

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Sequence Analysis of the Rat Phenylalanine Hydroxylase Gene Promoter

We have characterized the 5′-end (3218bp) of the rat phenylalanine hydroxylase (PAH) gene. Within this PAH promoter sequence, we have identified a number of putative regulatory sites analogous to those present in the human and murine PAH promoters. In particular, potential HNF 1 binding sites and a CRE have been identified. These sequences respectively bind HNF1 and CREB transcription factors present in rat nuclear extracts and may be significant in the tissue-specific and hormonal control of PAH expression.

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DNA Sequence

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