M. P. Valero, A. Fletcher, B. D. De Stavola, J. Vioque, Vicente Chaqués Alepuz
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Participants were interviewed about their diet using a Food Frequency Questionnaire, and other information on potential confounders, such as smoking, alcohol, and education. Blood samples were analyzed by a colorimetric method for vitamin C and by reversed-phase HLPC for other blood antioxidants. Blood levels of vitamin C above 49 micromol/L were associated with a 64% reduced odds for cataract (P < 0.0001). Dietary intake of vitamins C, E and selenium were marginally associated with decreased odds (P = 0.09, P = 0.09, P = 0.07, respectively), whereas moderately high levels of blood lycopene (>0.30 micromol/L) were associated with a 46% increased odds of cataract (P = 0.04). 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引用次数: 116
摘要
白内障是老年人的一个重要视力问题,在许多国家也是一项重要的医疗保健费用。大多数调查白内障危险因素的研究都是在美国进行的,关于饮食因素在欧洲人群中可能起的作用的信息较少。我们进行了一项病例对照研究,以调查地中海人群中抗氧化维生素(维生素C、维生素E、维生素a、β -胡萝卜素、α -胡萝卜素、β -隐黄质、番茄红素、玉米黄质和叶黄素)和矿物质(锌和硒)与白内障风险的关系。从西班牙瓦伦西亚的一家眼科外展诊所选择了343例白内障患者和334例年龄/性别频率匹配的对照组,年龄在55至74岁之间。研究人员使用食物频率问卷对参与者的饮食进行了采访,并对其他潜在的混杂因素(如吸烟、饮酒和受教育程度)进行了采访。血液样本用比色法分析维生素C,用反相HLPC法分析其他血液抗氧化剂。血液中维生素C水平高于49微mol/L与白内障发病率降低64%相关(P < 0.0001)。饮食中维生素C、E和硒的摄入与白内障发病率降低有轻微的相关性(P = 0.09, P = 0.09, P = 0.07),而血液中番茄红素水平较高(>0.30微mol/L)与白内障发病率增加46%相关(P = 0.04)。我们的研究结果加强了维生素C对老化晶状体的保护作用的证据,因为这种作用在维生素C摄入量高的人群中可见。
Vitamin C is associated with reduced risk of cataract in a Mediterranean population.
Cataract is an important visual problem of older people and a substantial health care cost in many countries. Most studies investigating risk factors for cataract have been conducted in the United States, and there is less information on the possible role of dietary factors in European populations. We conducted a case-control study to investigate the association of antioxidant vitamins (vitamin C, vitamin E, vitamin A, beta-carotene, alpha-carotene, beta-cryptoxanthin, lycopene, zeaxanthin and lutein) and minerals (zinc and selenium) and risk of cataract in a Mediterranean population. Cases with cataract (343) and 334 age/sex frequency-matched controls aged 55 to 74 y were selected from an ophthalmic outreach clinic in Valencia, Spain. Participants were interviewed about their diet using a Food Frequency Questionnaire, and other information on potential confounders, such as smoking, alcohol, and education. Blood samples were analyzed by a colorimetric method for vitamin C and by reversed-phase HLPC for other blood antioxidants. Blood levels of vitamin C above 49 micromol/L were associated with a 64% reduced odds for cataract (P < 0.0001). Dietary intake of vitamins C, E and selenium were marginally associated with decreased odds (P = 0.09, P = 0.09, P = 0.07, respectively), whereas moderately high levels of blood lycopene (>0.30 micromol/L) were associated with a 46% increased odds of cataract (P = 0.04). Our results strengthen the evidence for a protective role for vitamin C on the aging lens as this effect was seen in a population characterized by high vitamin C intakes.