Synthetic CT in assessment of anatomical and dosimetric variations in radiotherapy - procedure validation

Abstract Introduction: One of many procedures to control the quality of radiotherapy is daily imaging of the patient’s anatomy. The CBCT (Cone Beam Computed Tomography) plays an important role in patient positioning, and dose delivery monitoring. Nowadays, CBCT is a baseline for the calculation of fraction and total dose. Thus, it provides the potential for more comprehensive monitoring of the delivered dose and adaptive radiotherapy. However, due to the poor quality and the presence of numerous artifacts, the replacement of the CBCT image with the corrected one is desired for dose calculation. The aim of the study was to validate a method for generating a synthetic CT image based on deformable image registration. Material and methods: A Head & Torso Freepoint phantom, model 002H9K (Computerized Imaging Reference Systems, Norfolk, USA) with inserts was imaged with CT (Computed Tomography). Then, contouring and treatment plan were created in Eclipse (Varian Medical Systems, Palo Alto, CA, USA) treatment planning system. The phantom was scanned again with the CBCT. The planning CT was registered and deformed to the CBCT, resulting in a synthetic CT in Velocity software (Varian Medical Systems, Palo Alto, CA, USA). The dose distribution was recalculated based on the created CT image. Results: Differences in structure volumes and dose statistics calculated both on CT and synthetic CT were evaluated. Discrepancies between the original and delivered plan from 0.0 to 2.5% were obtained. Dose comparison was performed on the DVH (Dose-Volume Histogram) for all delineated inserts. Conclusions: Our findings suggest the potential utility of deformable registration and synthetic CT for providing dose reconstruction. This study reports on the limitation of the procedure related to the limited length of the CBCT volume and deformable fusion inaccuracies.