Assessment of the long Pentraxin 3 level in Polycystic Ovarian Syndrome-related infertility

Objective. To evaluate the role of Pentraxin 3 level in PCOS-related infertility and its correlation with the disease's hormonal profile. Patients and Methods. A case-control study involves a total of 90 women for one year, 30 women diagnosed with PCOS who are fertile, 30 women diagnosed with PCOS who are infertile, and 30 healthy controls, all women in the early follicular phase were sent for baseline investigations: FSH, LH, AMH, Fasting blood sugar, Insulin, Testosterone, TSH, and Pentraxin 3 that were measured by sandwich electrochemiluminescence immunoassay. Results. There were statistically significant variations in LH, LH/FSH ratio, Testosterone levels, and AMH across the groups. The mean of Pentraxin for the fertile PCOS group (4.14 ± 1.97) ng/mL was significantly higher than for the infertile PCOS group (1.39 ± 1.10 ng/Ml) and control (1.99 ± 1.66 ng/mL). For the infertile PCOS group, the correlation of Pentraxin was significantly positive with age and negative with AMH. ROC Curve analysis showed a cutoff value of 1.05 ng/ml with a sensitivity of 46.67% and specificity of 83.33% for the infertile group. Conclusions. Pentraxin 3 level is significantly higher in fertile PCOS patients and lower in the infertile PCOS group in comparison to the control group suggesting its possible role in PCOS-related infertility .