Perbandingan Profil Penetrasi Formula Krim Antioksidan dari Ekstrak Perikarpium Buah Manggis (Garcinia mangostana) dengan Variasi Penetration Enhancer

Garcinia mangostana Penetration enhancer Antioxidant cream Sun exposure with UV radiation is one of the triggers for free radicals that cause premature aging (photoaging), characterized by hyperpigmentation, wrinkles, and decreased skin elasticity. The solution to this problem is the use of antioxidants that can prevent the formation of free radicals. The purpose of this study was to formulate an antioxidant cream dosage form from pericarpium extract of mangosteen pericarpium with different penetration enhancers to obtain the best percentage of penetration and retention in the skin. Pericarpium extract of mangosteen fruit was prepared by maceration method using 70% ethanol, then the antioxidant activity and the phenolic content were measured and were used as an active ingredient in the cream formula. Formula F1-F3 were made, their physical characteristics were evaluated, and in vitro penetration testing was carried out. In vitro penetration testing was carried out on F2 and F3 containing extracts. The IC50 value of the extract against DPPH was found to be 7.514 μg/mL and the phenolic content was found to be 112,70 ± 0,80 mgGAE/g. The percentage of penetration, retention percentage, and flux value were 9.96% ± 0.075%, 37.951% ± 0.103%, 3.037 ± 0.023 μg/cm2.hour respectively for F2 and 7.872% ± 0.078% , 33.874% ± 0.259%, 2.400 ± 0.024 μg/cm2.hour, respectively for F3. From the results of statistical analysis, it was concluded that F2 was the best formula with homogeneous physical characteristics, had a yellowish color, emulsion type w/o, pH value of 6, adhesion of 11.05 ± 0.87 seconds, and diameter of spreadability of 6.20 ± 0.10 cm.