多形性胶质母细胞瘤(GBM)的存活率和增强分数(enf)

S. Mills, G. Thompson, G. Buonaccorsi, Parker Gjm, A. Jackson
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引用次数: 0

摘要

在GBM中,造影剂浓度曲线下初始面积的增强分数(IAUC) EnF IAUC 60与MRI参数K trans(造影剂传递系数)相关。当IAUC 60>2.5mMol时,阈值体素增强。5 (EnF IAUC 60>2.5)区分高级别和低级别胶质瘤。目的是评估得出基于信号强度的增强分数(EnF SI)的可行性,评估其与EnF IAUC 60指标的关系,并检查与GBM患者生存的关系。30例GBM术前和造影后进行t1加权成像,并进行t1 -DCE-MRI检查。根据IAUC 60图谱生成EnF IAUC 60>0和EnF IAUC 60>2.5。EnF SI由对比前和对比后的t1加权序列得出。Bland/Altman图评估EnF措施之间的一致性。多变量Cox回归分析检验EnF测量的预后价值。EnF IAUC 60>0与EnF SI的平均差异为0.0378(范围为-0.112-0.264,std. dev为0.07573),EnF IAUC 60>2.5与EnF SI的平均差异为-0.2492(范围为-0.6096-0.2416,std. dev为0.2154)。EnF SI与EnF IAUC 60>0和EnF IAUC 60>2.5均表现出良好的相关性,但与任何一个指标都不能直接互换。EnF IAUC升高60>0与延长生存期相关(p=0.008)。EnF SI无显著性趋势(p=0.061)。EnF SI可以从常规成像中得出,并与基于IAUC 60的指标相关。此外,增强分数传达了GBM的潜在预后信息。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Survival and Enhancing Fraction (enf) in Glioblastoma Multiforme (GBM)
In GBM, enhancing fraction derived from the initial area under the contrast agent concentration curve ( IAUC ), EnF IAUC 60 , correlates with the MRI parameter K trans (contrast agent transfer coefficient). Thresholding voxels as enhancing when IAUC 60>2.5mMol.s (EnF IAUC 60>2.5 ) separates high from low grade glioma. The objectives were to evaluate the feasibility of deriving a signal intensity based enhancing fraction (EnF SI ), assess its relationship with EnF IAUC 60 measures and examine relationships with survival in GBM. 30 GBM had pre-operative pre and post-contrast T 1 -weighted imaging and a T 1 -DCE-MRI protocol. EnF IAUC 60>0 and EnF IAUC 60>2.5 were generated from IAUC 60 maps. EnF SI was derived from pre and post-contrast T1-weighted sequences. Bland/Altman plots assessed agreement between EnF measures. A multivariate Cox regression analysis examined the prognostic value of EnF measures. The mean difference between EnF IAUC 60>0 and EnF SI was 0.0378 (range -0.112-0.264, std. dev 0.07573) and between EnF IAUC 60>2.5 and EnF SI was -0.2492 (range -0.6096-0.2416, std. dev 0.2154). EnF SI demonstrated good correlation with both EnF IAUC 60>0 and EnF IAUC 60>2.5 but was not directly interchangeable with either metric. Increased EnF IAUC 60>0 was associated with prolonged survival (p=0.008). A non-significant trend was seen with EnF SI (p=0.061). EnF SI can be derived from conventional imaging and correlates with IAUC 60 based metrics. Furthermore, enhancing fraction conveys potential prognostic information in GBM.
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