牛膝草提取物的抗氧化和抗黑色素活性研究

S. Shin, H. Kim, S. Kang, H. Cho, E. Kim, S. H. Park, K. Park
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引用次数: 5

摘要

牛膝草是牛膝草属的草本植物。由于其作为防腐剂、止咳剂和祛痰剂的特性,它通常被用作芳香草药和药用植物。本研究通过体外实验和细胞培养系统研究牛膝草提取物(HE)的抗氧化和抗黑素生成特性。结果表明,HE具有较高的DPPH和ABTS自由基清除活性,且呈剂量依赖性。此外,HE还能抑制B16F10黑色素瘤细胞内ROS的产生、黑色素含量以及酪氨酸酶活性。我们还发现HE抑制MITF、酪氨酸酶和TRP-2基因的mRNA表达。这些发现表明HE可能有助于防止皮肤氧化损伤和黑色素生成。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antioxidant and Anti-Melanogenic Activities of Hyssopus officinalis Extracts
Hyssopus officinalis is a herbaceous plant of the genus Hyssopus. Due to its properties as an antiseptic, cough reliever and expectorant, it is commonly used as an aromatic herb and medicinal plant. This study was performed to investigate the anti-oxidative and anti-melanogenic properties of Hyssopus officinalis extracts (HE) using in vitro assays and cell culture systems. As a result, HE showed higher DPPH and ABTS radicals scavenging activity in a dose-dependent manner. Also, HE inhibited the prodution of intracellular ROS and melanin contents in B16F10 melanoma cell as well as tyrosinase activity. We also found that HE inhibit mRNA expression of MITF, tyrosinase and TRP-2 gene. These findings suggest that HE may be beneficial for preventing oxidative damage and melanogenesis of skin.
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