Common Variable Immunodeficiency

Common variable immunodeficiency (CVID) refers to a heterogeneous immunodeficiency syndrome characterized by hypogammaglobulinemia, recurrent bacterial infections and a variety of immunological abnormalities. Affected persons are prone to recurrent bacterial infections, especially involving the upper and lower respiratory tracts. In addition, patients exhibit increased susceptibility to a protean array of autoimmune, gastrointestinal, neoplastic, and inflammatory disorders .