耐力运动对镉致不育成年雄性大鼠睾丸组织脂质过氧化水平及总抗氧化能力的影响

Amir Delshad, F. Salimi, Nasrin Heydariyeh, Shima Ababzadeh
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摘要

背景与目的:镉(Cd)可以通过产生自由基诱导睾丸脂质过氧化,增加丙二醛(MDA),降低总氧化能力(TAC),从而导致不育。本研究旨在探讨一段时间耐力运动对氯化镉致不育成年雄性大鼠睾丸组织MDA水平和TAC的影响。方法:选用体重250±30 g、12周龄的健康成年雄性Wistar大鼠32只,随机分为对照组(n=8)、运动组(n=8)、Cd组(n=8)和Cd+运动组(n=8)。耐力锻炼计划每周进行五次,持续五周。数据分析采用SPSS软件第24版,采用单因素方差分析和最小显著差异事后检验。显著性水平设为0.05。结果:运动组MDA和TAC较对照组显著升高(P<0.05),说明中等强度耐力运动显著升高cd致不育睾丸组织TAC和MDA。Cd增加了氧化应激标志物,降低了抗氧化酶。中等强度耐力运动显著增加抗氧化酶。结论:考虑到中等强度耐力运动对cd致不育大鼠的影响,可以说,这些运动可以使机体对氧化应激产物的抵抗力增强。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of Endurance Exercise on Lipid Peroxidation Level and Total Antioxidant Capacity of Testicular Tissue in Adult Male Rats With Cadmium-induced Infertility
Background and Objectives: Cadmium (Cd) can induce lipid peroxidation, increase malondialdehyde (MDA), and reduce total oxidative capacity (TAC) in the testis by producing free radicals and, as a result, cause infertility. This study aims to determine the effect of a period of endurance exercise on MDA levels and TAC of testicular tissue in adult male rats with infertility induced by cadmium chloride. Methods: In this experimental study, 32 healthy adult male Wistar rats weighing 250±30 g and aged 12 weeks were used, which were randomly divided into four groups of control (n=8), exercise (n=8), Cd (n=8), and Cd+exercise (n=8). The endurance exercise program was presented at five sessions per week for 5 weeks. Data were analyzed in SPSS software, version 24 using one-way analysis of variance and by the Least Significant Difference post hoc test. The significance level was set at 0.05. Results: The MDA and TAC in the exercise group were increased significantly compared to the control group (P<0.05), indicating that moderate-intensity endurance exercise significantly increased the TAC and MDA of testicular tissue in Cd-induced infertility. Cd increased oxidative stress markers and reduced antioxidant enzymes. Moderate-intensity endurance exercise significantly increased the antioxidant enzymes. Conclusion: Given the effects of moderate-intensity endurance exercise in rats with Cd-induced infertility, it can be said that these exercises can make the body more resistant to oxidative stress products.
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