缺乏25-羟基维生素D是自闭症的危险因素吗?初步研究

Q4 Medicine

Egyptian Journal of Ear, Nose, Throat and Allied Sciences Pub Date : 2021-07-12 DOI:10.21608/EJENTAS.2021.44200.1264

Megahed M. Hassan, A. Emam, A. Radwan, Amany Abdelhameed, S. Eldin, Montasser M Mohamed

{"title":"缺乏25-羟基维生素D是自闭症的危险因素吗?初步研究","authors":"Megahed M. Hassan, A. Emam, A. Radwan, Amany Abdelhameed, S. Eldin, Montasser M Mohamed","doi":"10.21608/EJENTAS.2021.44200.1264","DOIUrl":null,"url":null,"abstract":"Objective: To investigate the status of 25-hydroxy-vitamin-D [25-(OH)-D] in autistic children and to correlate with their mothers vitamin statuses and autism severity.Methods: In this case-control study, serum 25(OH)-D was measured in autistic children and controls (n=36 each) and in mothers of autistics and control mothers (n=24 each). Comparison and correlation studies were performed.Results: Both autistic children and their mothers have lower 25-(OH)-D compared to their controls with significant differences (P<0.001 for children and P=0.025 for mothers). Vitamin statuses in both autistic children and their mothers showed moderate to strong positive correlation (P<0.001). Moreover, the 25-OH-D showed inverse correlation with the autism severity (P=0.0026).Conclusion: Deficiency of 25(OH)-D is common in autistic children and related to the severity of symptoms. Vitamin D deficiency in children might be maternal-dependent. Deficiency of 25(OH)-D in autistic children and their mothers could be the primary predisposing factor for autism. This may find a common link among the genetic, immunological, anatomical, biochemical and physiological factors putting the puzzles together. Early supplementation of vitamin D could improve autistic manifestations.","PeriodicalId":37983,"journal":{"name":"Egyptian Journal of Ear, Nose, Throat and Allied Sciences","volume":"51 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2021-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Is Deficiency of 25-Hydroxy Vitamin D A Risk Factor for Autism? A Preliminary Study\",\"authors\":\"Megahed M. Hassan, A. Emam, A. Radwan, Amany Abdelhameed, S. Eldin, Montasser M Mohamed\",\"doi\":\"10.21608/EJENTAS.2021.44200.1264\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective: To investigate the status of 25-hydroxy-vitamin-D [25-(OH)-D] in autistic children and to correlate with their mothers vitamin statuses and autism severity.Methods: In this case-control study, serum 25(OH)-D was measured in autistic children and controls (n=36 each) and in mothers of autistics and control mothers (n=24 each). Comparison and correlation studies were performed.Results: Both autistic children and their mothers have lower 25-(OH)-D compared to their controls with significant differences (P<0.001 for children and P=0.025 for mothers). Vitamin statuses in both autistic children and their mothers showed moderate to strong positive correlation (P<0.001). Moreover, the 25-OH-D showed inverse correlation with the autism severity (P=0.0026).Conclusion: Deficiency of 25(OH)-D is common in autistic children and related to the severity of symptoms. Vitamin D deficiency in children might be maternal-dependent. Deficiency of 25(OH)-D in autistic children and their mothers could be the primary predisposing factor for autism. This may find a common link among the genetic, immunological, anatomical, biochemical and physiological factors putting the puzzles together. Early supplementation of vitamin D could improve autistic manifestations.\",\"PeriodicalId\":37983,\"journal\":{\"name\":\"Egyptian Journal of Ear, Nose, Throat and Allied Sciences\",\"volume\":\"51 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-07-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Egyptian Journal of Ear, Nose, Throat and Allied Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.21608/EJENTAS.2021.44200.1264\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Egyptian Journal of Ear, Nose, Throat and Allied Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21608/EJENTAS.2021.44200.1264","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

摘要

目的:探讨自闭症儿童25-羟基维生素d [25-(OH)- d]水平及其与母亲维生素水平和自闭症严重程度的关系。方法:在本病例对照研究中，测定了自闭症儿童和对照组(各36例)以及自闭症母亲和对照组(各24例)的血清25(OH)-D。进行了比较和相关性研究。结果:自闭症儿童及其母亲的25-(OH)- d水平均低于对照组，差异有统计学意义(儿童P<0.001，母亲P=0.025)。自闭症儿童及其母亲的维生素水平均呈中等至强烈的正相关(P<0.001)。25-OH-D与自闭症严重程度呈负相关(P=0.0026)。结论:25(OH)-D缺乏在自闭症儿童中很常见，且与自闭症症状的严重程度有关。儿童缺乏维生素D可能与母亲有关。自闭症儿童及其母亲缺乏25(OH)-D可能是自闭症的主要诱发因素。这可能会在遗传、免疫、解剖、生化和生理因素之间找到共同的联系，把这些谜团放在一起。早期补充维生素D可以改善自闭症的表现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Is Deficiency of 25-Hydroxy Vitamin D A Risk Factor for Autism? A Preliminary Study

Objective: To investigate the status of 25-hydroxy-vitamin-D [25-(OH)-D] in autistic children and to correlate with their mothers vitamin statuses and autism severity.Methods: In this case-control study, serum 25(OH)-D was measured in autistic children and controls (n=36 each) and in mothers of autistics and control mothers (n=24 each). Comparison and correlation studies were performed.Results: Both autistic children and their mothers have lower 25-(OH)-D compared to their controls with significant differences (P<0.001 for children and P=0.025 for mothers). Vitamin statuses in both autistic children and their mothers showed moderate to strong positive correlation (P<0.001). Moreover, the 25-OH-D showed inverse correlation with the autism severity (P=0.0026).Conclusion: Deficiency of 25(OH)-D is common in autistic children and related to the severity of symptoms. Vitamin D deficiency in children might be maternal-dependent. Deficiency of 25(OH)-D in autistic children and their mothers could be the primary predisposing factor for autism. This may find a common link among the genetic, immunological, anatomical, biochemical and physiological factors putting the puzzles together. Early supplementation of vitamin D could improve autistic manifestations.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Egyptian Journal of Ear, Nose, Throat and Allied Sciences Medicine-Otorhinolaryngology

CiteScore

0.20

自引率

0.00%

发文量

期刊介绍： Egyptian Journal of Ear, Nose, Throat and Allied Sciences aspires to play a national, regional and international role in the promotion of responsible and effective research in the field of Otolaryngology, Head and Neck Surgery in Egypt, Middle East and Africa. Mission To encourage and support research in Ear, Nose and Throat (ENT) field and interdisciplinary topics To implement high-quality editorial practices among Otolaryngologists To upgrade the ability and experience of local doctors in international publishing To offer professional publishing support to local researchers, creating a supportive network for career development To highlight ENT diseases and problems peculiar to our region To promote research in endemic, hereditary and infectious ENT problems related to our region To expose and study impact of ethnic, social, environmental and cultural issues on expression of different ENT diseases To organize common epidemiologic research of value to the region To provide resource to national and regional authorities about problems in the field of ENT and their implication on public health and resources To facilitate exchange of knowledge in our part of the world To expand activities with regional and international scientific societies.