缺血性脑血管病n端脑钠肽原(NT-Pro BNP)水平与梗死类型及梗死体积的关系

S. Tekin, Çağatay Öncel, M. B. Özdemir, Y. Yaylali, Işık Tekin, Özcan Güneş, S. Rota, Nuriye Kurbetli
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引用次数: 1

摘要

背景:n端脑钠肽原是一种主要由心脏产生的神经激素,在急性缺血性脑血管病中增高。本研究旨在探讨脑钠前肽n端水平与脑血管疾病亚型、梗死面积及预后的关系,并探讨脑钠前肽n端是否可作为缺血性脑血管疾病的生物标志物。方法:连续105例诊断为急性缺血性脑血管病的患者和50例健康对照者,采用美国国立卫生研究院卒中量表评估血清n端脑钠肽原浓度、脑血管疾病亚型、梗死面积和临床转归。结果:心栓塞组n端脑钠肽原均值显著高于腔隙性梗死组(P < 0.005)和短暂性脑缺血发作组(P = 0.005)。美国国立卫生研究院卒中量表恶化与n端脑钠肽前体升高之间存在相关性(P = 0.001)。然而,脑钠肽n端前体水平与梗死体积之间无显著相关性(P = 0.44)。结论:n端脑利钠肽原可作为区分心栓塞性梗死和腔隙性梗死的有价值的标志物。此外,n端脑钠肽前体水平可能作为短暂性脑缺血发作组鉴别诊断的生物标志物,并提供对预后的洞察。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Relationship Between N-Terminal Probrain Natriuretic Peptide (NT-Pro BNP) Level, Infarct Type and Infarct Volume in Ischemic Cerebrovascular Disease
Background: N-terminal probrain natriuretic peptide, which is a neurohormone produced mainly by the heart, is increased in acute ischemic cerebrovascular disease. Here we aimed to investigate the relationship of N-terminal probrain natriuretic peptide levels with cerebrovascular disease subtypes, infarct volume, and prognosis in cerebrovascular disease, and to determine if N-terminal probrain natriuretic peptide could be a biomarker for ischemic cerebrovascular disease. Methods: Consecutive 105 patients with a diagnosis of acute ischemic cerebrovascular disease and 50 healthy controls were examined for serum N-terminal probrain natriuretic peptide concentration, cerebrovascular disease subtypes, infarct volumes, and clinical outcomes with the National Institute of Health Stroke Scale assessment. Results: Mean N-terminal probrain natriuretic peptide values of cardioembolic group were significantly higher than lacunar infarct group (P < .005) and transient ischemic attack group (P = .005). There was a relation between worsening in the National Institute of Health Stroke Scale and elevation at N-terminal probrain natriuretic peptide (P = .001). However, between N-terminal probrain natriuretic peptide levels and infarct volume, significant correlation was not detected (P = .44). Conclusion: N-terminal probrain natriuretic peptide can be used as a valuable marker to distinguish between cardioembolic infarct and lacunar infarct. In addition, N-terminal probrain natriuretic peptide levels might be used as a biomarker for differential diagnosis of transient ischemic attack group and to provide insight into the prognosis.
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