{"title":"第14章。还原脱卤过程中非共价相互作用辅助氧化还原催化","authors":"S. Kurek, Piotr P Romańczyk","doi":"10.1039/9781788016490-00302","DOIUrl":null,"url":null,"abstract":"This chapter demonstrates how common are noncovalent interactions assisting catalytic reductive dehalogenation, including enzymatic reactions in reductive dehalogenases. Examples are given of halogen bonding, specific to the reactants in this process, facilitating it, but also hydrogen bonding, which may make the carbon–halogen bond more prone to cleavage or even provide a path for the electron transfer. Various types of noncovalent interactions locate the enzyme substrate in a position ideal for dehalogenation to proceed. Such systems are described, and also model systems, in which proximity effects have been shown to operate. The importance of quantum-chemical calculations in the discovery of noncovalent effects and revealing their significance for the efficiency and selectivity of reductive dehalogenation is also stressed.","PeriodicalId":10054,"journal":{"name":"Catalysis Series","volume":"14 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"CHAPTER 14. Noncovalent Interaction-assisted Redox Catalysis in Reductive Dehalogenation\",\"authors\":\"S. Kurek, Piotr P Romańczyk\",\"doi\":\"10.1039/9781788016490-00302\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This chapter demonstrates how common are noncovalent interactions assisting catalytic reductive dehalogenation, including enzymatic reactions in reductive dehalogenases. Examples are given of halogen bonding, specific to the reactants in this process, facilitating it, but also hydrogen bonding, which may make the carbon–halogen bond more prone to cleavage or even provide a path for the electron transfer. Various types of noncovalent interactions locate the enzyme substrate in a position ideal for dehalogenation to proceed. Such systems are described, and also model systems, in which proximity effects have been shown to operate. The importance of quantum-chemical calculations in the discovery of noncovalent effects and revealing their significance for the efficiency and selectivity of reductive dehalogenation is also stressed.\",\"PeriodicalId\":10054,\"journal\":{\"name\":\"Catalysis Series\",\"volume\":\"14 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-03-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Catalysis Series\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1039/9781788016490-00302\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Catalysis Series","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1039/9781788016490-00302","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
CHAPTER 14. Noncovalent Interaction-assisted Redox Catalysis in Reductive Dehalogenation
This chapter demonstrates how common are noncovalent interactions assisting catalytic reductive dehalogenation, including enzymatic reactions in reductive dehalogenases. Examples are given of halogen bonding, specific to the reactants in this process, facilitating it, but also hydrogen bonding, which may make the carbon–halogen bond more prone to cleavage or even provide a path for the electron transfer. Various types of noncovalent interactions locate the enzyme substrate in a position ideal for dehalogenation to proceed. Such systems are described, and also model systems, in which proximity effects have been shown to operate. The importance of quantum-chemical calculations in the discovery of noncovalent effects and revealing their significance for the efficiency and selectivity of reductive dehalogenation is also stressed.