{"title":"儿茶酚胺致肺静脉心律失常的分子特征","authors":"Yosuke Okamoto","doi":"10.5105/jse.40.141","DOIUrl":null,"url":null,"abstract":"Molecular Characteristics of Catecholamine-Induced Arrhythmia in Pulmonary Vein It is known that pulmonary veins（PVs）are an origin of the most frequent arrhythmia, atrial fibrillation. However, molecular characteristics of the arrhythmogenicity unique to PV myocytes is still unclear. We have investigated the molecular mechanism of catecholamine-induced arrhythmia using both electrophysiology and molecular biology with isolated PV cardiomyocytes of rats. In this paper, I mainly discuss cross-talk among a cluster of Ca 2+ -releasing channels on the sarcoplasmic reticulum and Na + -Ca 2+ exchanger on T-tubule（Ca 2+ releasing-NCX coupling）, a hyperpolarization activated Cl － current originated in ClC-2/HSPA8 complex, and influence of the adenylate cyclase.","PeriodicalId":14543,"journal":{"name":"Japanese Journal of Electrocardiology","volume":"87 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2020-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Molecular Characteristics of Catecholamine-Induced Arrhythmia in Pulmonary Vein\",\"authors\":\"Yosuke Okamoto\",\"doi\":\"10.5105/jse.40.141\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Molecular Characteristics of Catecholamine-Induced Arrhythmia in Pulmonary Vein It is known that pulmonary veins（PVs）are an origin of the most frequent arrhythmia, atrial fibrillation. However, molecular characteristics of the arrhythmogenicity unique to PV myocytes is still unclear. We have investigated the molecular mechanism of catecholamine-induced arrhythmia using both electrophysiology and molecular biology with isolated PV cardiomyocytes of rats. In this paper, I mainly discuss cross-talk among a cluster of Ca 2+ -releasing channels on the sarcoplasmic reticulum and Na + -Ca 2+ exchanger on T-tubule（Ca 2+ releasing-NCX coupling）, a hyperpolarization activated Cl － current originated in ClC-2/HSPA8 complex, and influence of the adenylate cyclase.\",\"PeriodicalId\":14543,\"journal\":{\"name\":\"Japanese Journal of Electrocardiology\",\"volume\":\"87 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-10-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Japanese Journal of Electrocardiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5105/jse.40.141\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Japanese Journal of Electrocardiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5105/jse.40.141","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Molecular Characteristics of Catecholamine-Induced Arrhythmia in Pulmonary Vein
Molecular Characteristics of Catecholamine-Induced Arrhythmia in Pulmonary Vein It is known that pulmonary veins（PVs）are an origin of the most frequent arrhythmia, atrial fibrillation. However, molecular characteristics of the arrhythmogenicity unique to PV myocytes is still unclear. We have investigated the molecular mechanism of catecholamine-induced arrhythmia using both electrophysiology and molecular biology with isolated PV cardiomyocytes of rats. In this paper, I mainly discuss cross-talk among a cluster of Ca 2+ -releasing channels on the sarcoplasmic reticulum and Na + -Ca 2+ exchanger on T-tubule（Ca 2+ releasing-NCX coupling）, a hyperpolarization activated Cl － current originated in ClC-2/HSPA8 complex, and influence of the adenylate cyclase.
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