坏疽性脓皮病伴脾脏受累。回顾文献和病例报告。

R. Cosgarea, S. Șenilă, R. Badea, L. Ungureanu
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引用次数: 10

摘要

背景:坏疽性脓皮病是一种罕见的、溃疡性的、破坏性的、非传染性的皮肤病,是中性粒细胞性皮肤病的一种临床表现。内脏受累,表现为无菌中性粒细胞浸润除皮肤外的其他部位,并不常见。累及脾是非常罕见的。我们报告了一位58岁女性坏疽性脓皮病伴脾脏受累的病例,并回顾了所有类似病例的报告。我们发现了9例报告病例,我们的病例是第10例。结论本综述显示坏疽性脓皮病病程中脾脏受累可发生在任何年龄。它在男性中更为常见。几乎一半的患者存在潜在的或相关的嗜中性粒细胞紊乱。皮肤表现通常在脾脏受累前出现。在大多数情况下,这种疾病对糖皮质激素反应良好。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pyoderma gangrenosum with spleen involvement. Review of the literature and case report.
BACKGROUND Pyoderma gangrenosum is a rare, ulcerative, destructive, non-infectious dermatologic disease and it is one clinical entity within the spectrum of neutrophilic dermatoses. Visceral involvement, manifesting as sterile neutrophilic infiltrates in sites other than skin and, is infrequent. Splenic involvement is very rare. MAIN OBSERVATIONS We present a case of a 58-year-old woman with pyoderma gangrenosum with spleen involvement and review all reports of similar cases.We have found nine reported cases, our case being the tenth. CONCLUSION Our review showed that spleen involvement in the course of pyoderma gangrenosum can occur at any age. It is slightly more frequent in men. An underlying or associated neutrophilic disorder is present in almost half of the patients. Skin manifestations were usually present before splenic involvement. In most cases the disese responds well to glucocorticosteroids.
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