免疫调节生物材料~凋亡细胞激发的抗炎聚合物~

M. Ebara, Akari Tasaki
{"title":"免疫调节生物材料~凋亡细胞激发的抗炎聚合物~","authors":"M. Ebara, Akari Tasaki","doi":"10.5650/oleoscience.21.447","DOIUrl":null,"url":null,"abstract":"The field of biomaterials has seen a strong rejuvenation due to the new potential to modulate immune system in our body. This special class of materials is called“immunomodulatory biomaterials”. Generally, three fundamental strategies are followed in the design of immunomodulatory biomaterials: (1) immuno-iner t biomaterials, (2) immuno-activating biomaterials, and (3) immuno-tolerant biomaterials. While many applications of immuno-inert biomaterials such as biocompatible medical implants have been already proposed in the past decades, the ability to engineer biological activity into synthetic materials greatly increases the number of their potential uses and improves their per formance in more traditional applications. The major focus of researchers is now set on developing immuno-tolerant biomaterials for anti-inflammatory therapies. In this review, we therefore introduce recent developments of immuno-tolerant biomaterials. Especially we introduce an apoptotic cell membrane inspired polymer and its post-inflammatory ef fects on immune cells in this ar ticle.","PeriodicalId":19666,"journal":{"name":"Oleoscience","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Immuno-modulating Biomaterials~Apoptotic Cell-inspired Anti-inflammatory Polymers~\",\"authors\":\"M. Ebara, Akari Tasaki\",\"doi\":\"10.5650/oleoscience.21.447\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The field of biomaterials has seen a strong rejuvenation due to the new potential to modulate immune system in our body. This special class of materials is called“immunomodulatory biomaterials”. Generally, three fundamental strategies are followed in the design of immunomodulatory biomaterials: (1) immuno-iner t biomaterials, (2) immuno-activating biomaterials, and (3) immuno-tolerant biomaterials. While many applications of immuno-inert biomaterials such as biocompatible medical implants have been already proposed in the past decades, the ability to engineer biological activity into synthetic materials greatly increases the number of their potential uses and improves their per formance in more traditional applications. The major focus of researchers is now set on developing immuno-tolerant biomaterials for anti-inflammatory therapies. In this review, we therefore introduce recent developments of immuno-tolerant biomaterials. Especially we introduce an apoptotic cell membrane inspired polymer and its post-inflammatory ef fects on immune cells in this ar ticle.\",\"PeriodicalId\":19666,\"journal\":{\"name\":\"Oleoscience\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Oleoscience\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5650/oleoscience.21.447\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oleoscience","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5650/oleoscience.21.447","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

由于具有调节人体免疫系统的新潜力,生物材料领域出现了强劲的复兴。这种特殊的材料被称为“免疫调节生物材料”。一般来说,免疫调节生物材料的设计遵循三种基本策略:(1)免疫修饰生物材料,(2)免疫激活生物材料,(3)免疫耐受生物材料。虽然在过去几十年中已经提出了许多免疫惰性生物材料的应用,例如生物相容性医疗植入物,但将生物活性设计到合成材料中的能力大大增加了其潜在用途的数量,并改善了其在更传统应用中的性能。研究人员目前的主要重点是开发用于抗炎治疗的免疫耐受生物材料。在这篇综述中,我们因此介绍了免疫耐受生物材料的最新进展。本文特别介绍了一种凋亡细胞膜激发聚合物及其对免疫细胞的炎症后作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Immuno-modulating Biomaterials~Apoptotic Cell-inspired Anti-inflammatory Polymers~
The field of biomaterials has seen a strong rejuvenation due to the new potential to modulate immune system in our body. This special class of materials is called“immunomodulatory biomaterials”. Generally, three fundamental strategies are followed in the design of immunomodulatory biomaterials: (1) immuno-iner t biomaterials, (2) immuno-activating biomaterials, and (3) immuno-tolerant biomaterials. While many applications of immuno-inert biomaterials such as biocompatible medical implants have been already proposed in the past decades, the ability to engineer biological activity into synthetic materials greatly increases the number of their potential uses and improves their per formance in more traditional applications. The major focus of researchers is now set on developing immuno-tolerant biomaterials for anti-inflammatory therapies. In this review, we therefore introduce recent developments of immuno-tolerant biomaterials. Especially we introduce an apoptotic cell membrane inspired polymer and its post-inflammatory ef fects on immune cells in this ar ticle.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信