综述:维生素E类似物作为过渡期奶牛辅助抗氧化补充剂的潜在作用

Q2 Agricultural and Biological Sciences
M. Kuhn
{"title":"综述:维生素E类似物作为过渡期奶牛辅助抗氧化补充剂的潜在作用","authors":"M. Kuhn","doi":"10.3390/dairy4020020","DOIUrl":null,"url":null,"abstract":"Despite routine supplementation of dairy cattle with vitamins with antioxidant functions, such as α-tocopherol, the high energy demand of the transition period creates a pro-oxidant state that can overcome antioxidant defenses and damage macromolecules. Known as oxidative stress, this condition impairs host immune defenses, predisposing cattle to disease and causing dysfunctional inflammation through a dysregulated production of lipid inflammatory mediators known as oxylipids. Non-α-tocopherol analogs of vitamin E have functions in other species that limit oxidative stress and dysfunctional inflammation but have largely remained unstudied in cattle. As non-α-tocopherol analogs of vitamin E have functions similar to α-tocopherol yet are more rapidly metabolized, they may provide further antioxidative functions with a reduced risk for adverse effects. Indeed, in vitro and in vivo evidence in cattle show a strong safety profile of most non-α-tocopherol analogs, and by several measures, non-α-tocopherol analogs present equally or more potent antioxidative activities than α-tocopherol alone. Further, vitamin E analogs are shown to compete with certain fatty acids for enzymatic metabolism, which may impact proinflammatory mediator production. Given that non-α-tocopherol analogs of vitamin E reduce the production of pro-inflammatory mediators and act as potent antioxidants, their safety and efficacy for these purposes should be further evaluated in cattle.","PeriodicalId":11001,"journal":{"name":"Dairy Science & Technology","volume":"14 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Review: The Potential Role of Vitamin E Analogs as Adjunctive Antioxidant Supplements for Transition Cows\",\"authors\":\"M. Kuhn\",\"doi\":\"10.3390/dairy4020020\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Despite routine supplementation of dairy cattle with vitamins with antioxidant functions, such as α-tocopherol, the high energy demand of the transition period creates a pro-oxidant state that can overcome antioxidant defenses and damage macromolecules. Known as oxidative stress, this condition impairs host immune defenses, predisposing cattle to disease and causing dysfunctional inflammation through a dysregulated production of lipid inflammatory mediators known as oxylipids. Non-α-tocopherol analogs of vitamin E have functions in other species that limit oxidative stress and dysfunctional inflammation but have largely remained unstudied in cattle. As non-α-tocopherol analogs of vitamin E have functions similar to α-tocopherol yet are more rapidly metabolized, they may provide further antioxidative functions with a reduced risk for adverse effects. Indeed, in vitro and in vivo evidence in cattle show a strong safety profile of most non-α-tocopherol analogs, and by several measures, non-α-tocopherol analogs present equally or more potent antioxidative activities than α-tocopherol alone. Further, vitamin E analogs are shown to compete with certain fatty acids for enzymatic metabolism, which may impact proinflammatory mediator production. Given that non-α-tocopherol analogs of vitamin E reduce the production of pro-inflammatory mediators and act as potent antioxidants, their safety and efficacy for these purposes should be further evaluated in cattle.\",\"PeriodicalId\":11001,\"journal\":{\"name\":\"Dairy Science & Technology\",\"volume\":\"14 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-04-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Dairy Science & Technology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3390/dairy4020020\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Agricultural and Biological Sciences\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dairy Science & Technology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3390/dairy4020020","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Agricultural and Biological Sciences","Score":null,"Total":0}
引用次数: 0

摘要

尽管奶牛经常补充具有抗氧化功能的维生素,如α-生育酚,但过渡时期的高能量需求会产生促氧化状态,从而克服抗氧化防御并破坏大分子。这种情况被称为氧化应激,损害了宿主的免疫防御,使牛容易患病,并通过被称为氧脂质的脂质炎症介质的失调产生导致功能失调的炎症。维生素E的非α-生育酚类似物在其他物种中具有限制氧化应激和功能失调炎症的功能,但在牛身上的研究很大程度上尚未得到研究。由于维生素E的非α-生育酚类似物具有与α-生育酚相似的功能,但代谢速度更快,因此它们可能提供进一步的抗氧化功能,同时降低不良反应的风险。事实上,在牛体内和体外的证据表明,大多数非α-生育酚类似物具有很强的安全性,并且通过几种测量,非α-生育酚类似物具有与α-生育酚相同或更强的抗氧化活性。此外,维生素E类似物被证明与某些脂肪酸竞争酶代谢,这可能影响促炎介质的产生。鉴于维生素E的非α-生育酚类似物可以减少促炎介质的产生,并作为有效的抗氧化剂,因此它们在牛体内的安全性和有效性有待进一步评估。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Review: The Potential Role of Vitamin E Analogs as Adjunctive Antioxidant Supplements for Transition Cows
Despite routine supplementation of dairy cattle with vitamins with antioxidant functions, such as α-tocopherol, the high energy demand of the transition period creates a pro-oxidant state that can overcome antioxidant defenses and damage macromolecules. Known as oxidative stress, this condition impairs host immune defenses, predisposing cattle to disease and causing dysfunctional inflammation through a dysregulated production of lipid inflammatory mediators known as oxylipids. Non-α-tocopherol analogs of vitamin E have functions in other species that limit oxidative stress and dysfunctional inflammation but have largely remained unstudied in cattle. As non-α-tocopherol analogs of vitamin E have functions similar to α-tocopherol yet are more rapidly metabolized, they may provide further antioxidative functions with a reduced risk for adverse effects. Indeed, in vitro and in vivo evidence in cattle show a strong safety profile of most non-α-tocopherol analogs, and by several measures, non-α-tocopherol analogs present equally or more potent antioxidative activities than α-tocopherol alone. Further, vitamin E analogs are shown to compete with certain fatty acids for enzymatic metabolism, which may impact proinflammatory mediator production. Given that non-α-tocopherol analogs of vitamin E reduce the production of pro-inflammatory mediators and act as potent antioxidants, their safety and efficacy for these purposes should be further evaluated in cattle.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Dairy Science & Technology
Dairy Science & Technology 农林科学-食品科技
CiteScore
2.30
自引率
0.00%
发文量
0
审稿时长
2 months
期刊介绍: Information not localized
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信