手性酰胺基酰化铵环氧化反应立体选择性的来源。

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Monatshefte Fur Chemie Pub Date : 2017-01-01 Epub Date: 2016-11-24 DOI:10.1007/s00706-016-1866-8

Johanna Novacek, Raphaël Robiette, Mario Waser

引用次数: 0

摘要

摘要：详细的DFT研究为手性酰胺基酰化铵在环氧化反应中的应用提供了深入的机理理解。结果表明，所使用的手性助剂有效地屏蔽了ylide的一个面，从而产生了非常高的立体选择性，只产生了一个反式异构体，并且完全控制了绝对构型。图形化的简介:

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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On the origin of the stereoselectivity in chiral amide-based ammonium ylide-mediated epoxidations.

Abstract: Detailed DFT studies provide an in-depth mechanistic understanding for the use of chiral amide-based ammonium ylides in epoxidation reactions. It is shown that the used chiral auxiliary efficiently shields one face of the ylide, which thus results in an extraordinarily high stereoselectivity giving only one trans-isomer with perfect control of the absolute configuration.

Graphical abstract:

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来源期刊

Monatshefte Fur Chemie 化学-化学综合

CiteScore

3.70

自引率

5.60%

发文量

116

审稿时长

3.3 months

期刊介绍： "Monatshefte für Chemie/Chemical Monthly" was originally conceived as an Austrian journal of chemistry. It has evolved into an international journal covering all branches of chemistry. Featuring the most recent advances in research in analytical chemistry, biochemistry, inorganic, medicinal, organic, physical, structural, and theoretical chemistry, Chemical Monthly publishes refereed original papers and a section entitled "Short Communications". Reviews, symposia in print, and issues devoted to special fields will also be considered.