抗癌剂对蒙古鸟类丝虫病成虫的抑制作用。

K. Kinnamon, Robert R. Engle, B. Poon, William Y. Ellis, J. W. McCall, M. Dzimianski
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引用次数: 8

摘要

八种以前未报道的具有抗丝活性的化学结构已被确定。研究了79种具有抗癌活性的化合物对移植到蒙古雄鸟体内的pahangi Brugia和Acanthocheilonema viteae可能具有的杀灭活性。所有8种活性化合物对盘尾丝虫病型(棘丝虫病)均有抑制作用。淋巴型(pahangi Brugia)没有大丝虫。这些新的结构可能代表了一个核心,围绕它可以合成有效的药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Anticancer agents suppressive for adult parasites of filariasis in Mongolian jirds.
Eight chemical structures not previously reported to possess antifilarial activity have been identified. A total of 79 compounds with anticancer properties were evaluated for possible macrofilaricidal activity against Brugia pahangi and Acanthocheilonema viteae transplanted into male Mongolian jirds (Meriones unguiculatus). All eight active compounds were suppressive for the onchocerciasis type (Acanthocheilonema viteae) of the disease. None was macrofilaricidal for the lymphatic form (Brugia pahangi). These new structures may represent a nucleus around which effective drugs can be synthesized.
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