SECONDARY REACTIVE OXYGEN SPECIES PRODUCTION IN SERA OF PATIENTS WITH RESPECTABLE NON-SQUAMOUS CELL LUNG CANCERS

Oxidative stress (OS) had been evaluated in NSCLC using photoproduced singlet oxygen (1O2) deactivating by oxydizing its targets directly or through secondary reactive oxygen species (SOS) production. Either experimentally (orthotopic grafts in mice) or clinically OS changed non linearly with progression. At time of cachexia OS dramatically increased when at a resectable stage in was lower than in controls. In both cases it correlated with a worse prognosis. Vit C or Vit C+GSH have nearly no effect in resectable NSCLC patients but a negative one in controls. Vit E or Vit E + Vit C have a stronger protective effect in NSCLC, dose dependent but not related to the pathology. There was a trend to an inverse relationship OS/Vit D. An eventual adjuvant supplementation during cancers should by controlled on a per-patient basis.