二- (2S) -2-氨基-3- (1h -吲哚-3-酰基)丙酸二氢四碘化物的结构与性质

A. Sabitov, S. Turganbay, A. Dzhumagazieva
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引用次数: 0

摘要

合成了氨基酸-碱金属盐-碘-水体系中的新型有机碘配合物。研究了配合物二- (2S) -2-氨基-3- (1h -吲哚-3-酰基)丙酸二氢四碘化物的理化性质。显微分析表明,复合物颗粒呈细长针状线状棒状,平均粒径为2.50 ~ 4.00µm。MDCK细胞培养的细胞毒试验及对金黄色葡萄球菌ATCC 6538-Р(博物馆敏感菌株)的抑菌活性;金黄色葡萄球菌ATCC-BAA-39(博物馆多重耐药菌株);大肠杆菌ATCC 8739(博物馆敏感菌株);大肠杆菌ATCC-BAA-196(博物馆多重耐药菌株);铜绿假单胞菌ATCC 9027(博物馆敏感菌株);铜绿假单胞菌ta2。复合物具有低细胞毒性,直接抗病毒作用,对耐药微生物菌株具有抗菌活性。无论是否存在代谢激活,双- (2S) -2-氨基-3- (1h -吲哚-3-酰基)丙酸二氢四碘化物都不会对L5178Y系哺乳动物细胞产生任何诱变作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Structure and Properties of the di- ((2S) -2-amino-3- (1H-indol-3-yl)propionate)-dihydro-tetraiodide
New organic iodine complex in the amino acid - alkali metal salt - iodine - water systemwas synthesized. The physico-chemical properties of complexdi- ((2S) -2-amino-3- (1H-indol-3-yl) propionate)-dihydro-tetraiodide were studied. Microscopic analysis shows that particles of complex have elongated needle-like linear stick-like shapes with average size 2.50-4.00 µm. The cytotoxicity test on MDCK cell culture, antimicrobial activity on S. aureus ATCC 6538-Р (museum susceptible strain); S. aureus ATCC-BAA-39 (museum multiresistant strain); E. coli ATCC 8739 (museum susceptible strain); E. coli ATCC-BAA-196 (museum multiresistant strain); P. aeruginosa ATCC 9027 (museum susceptible strain); P. aeruginosa TA2were observed. Complex has low cytotoxicity, direct antiviral effect, and antimicrobial activity against antibiotic-resistant strains of microorganisms. Di- ((2S) -2-amino-3- (1H-indol-3-yl) propionate)-dihydro-tetraiodide does not cause any mutagenic effect on mammalian cells of the L5178Y line, both in the presence and in the absence of metabolic activation.
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