微藻提取物造血和免疫作用的研究

A. Lykov, I. Uvarov, R. Gevorgiz, S. Zheleznova, O. Poveshchenko
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引用次数: 0

摘要

微藻作为众多生物活性物质的来源,是开发新型生物活性补充剂的有希望的候选者。决定使用微藻的可能性的一个重要方面涉及对人体和动物身体的器官和系统没有不利影响。在开发阶段,应特别注意微藻用于生物医学用途的安全性,因为它对造血和免疫细胞的功能状态没有明显的负面影响。为此,本研究探讨了五种微藻油提取物对实验动物造血参数、脾脏和胸腺细胞数量和功能活性以及血清免疫球蛋白水平的影响。结果表明,小球藻(C. vulgaris)和梭形圆柱藻(C. closterium)提取物均能降低外周血白细胞的数量。Coelastrella sp., C. closterium和Porphyridium purpureum (P. purpureum)增加中性粒细胞的比例。发现紫癜引起嗜酸性粒细胞比例的增加。Arthrospira(螺旋藻)platensis (a . platensis)和C. closterium产生单核细胞比例下降。closterium和P. purpureum诱导实验小鼠外周血淋巴细胞比例降低。所有微藻提取物对红细胞生成和血红蛋白均无影响。此外,所有微藻提取物均能抑制脾细胞增殖,而其对胸腺细胞增殖的影响取决于微藻类型。在小鼠血清中,弹性体微藻提取物可提高IgG水平,紫藻提取物可降低IgM和IgA水平。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Study of the haematopoietic and immune effect of microalgae extracts
Microalgae, as a source of numerous biologically active substances, are promising candidates for the development of novel biologically active supplements. An important aspect determining the possibility of using microalgae involves the absence of adverse effects on the organs and systems of the human and animal body. At the development stage, special attention should be paid to the safety of microalgae for biomedical use in terms of the absence of significant negative effects on the haematopoiesis and the functional status of immune cells. In this regard, the present study investigates the effect of oil extracts obtained from five microalgae species on haematopoietic parameters, the number and functional activity of spleen and thymus cells, as well as on immunoglobulin levels in the blood serum of laboratory animals. According to the obtained results, Chlorella vulgaris (C. vulgaris) and Cylindrotheca closterium (C. closterium) extracts decrease the number of leukocytes in the peripheral blood. Coelastrella sp., C. closterium, and Porphyridium purpureum (P. purpureum) increase the proportion of neutrophils. P. purpureum was found to initiate an increase in the proportion of eosinophils. Arthrospira (Spirulina) platensis (A. platensis) and C. closterium produce a decrease in the proportion of monocytes. C. closterium and P. purpureum induce a reduction in the proportion of lymphocytes in the peripheral blood of laboratory mice. All microalgae extracts had no effect on erythropoiesis and haemoglobin. In addition, all microalgae extracts were found to reduce splenocyte proliferation, while their effect on thymocyte proliferation depended on the microalgae type. In the mice serum, Coelastrella sp. microalgae extract increases IgG levels, while P. purpureum and C. vulgaris decrease IgM and IgA levels, respectively.
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