脐带血白蛋白水平作为健康足月新生儿生理性黄疸的预测因子

K S Anupriya, N Pradeep
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引用次数: 1

摘要

背景:新生儿黄疸在世界范围内是一种非常常见的疾病,高达60%的足月新生儿和80%的早产新生儿在出生后第一周发生,是最常见的再入院原因。本研究旨在评估脐带血白蛋白水平对健康足月新生儿黄疸后续发展的预测价值。本研究旨在发现脐带血白蛋白在预测新生儿黄疸的后续发展方面的有用性。方法和方法:这是一项以医院为基础的前瞻性研究,在100名健康足月新生儿中进行。脐带血白蛋白水平在出生时测定。所有临床怀疑为黄疸的婴儿在72-96小时进行血清总胆红素测定。根据新生儿脐带白蛋白水平3.3 g/dL分为A、B、C三组。根据血清胆红素≥17 mg/dL、新生儿需要光疗和换血来推断研究的主要结局。结果:A组21例,B组35例,C组44例。A组总胆红素>17 mg/dL 18例(85.7%),其中16例(76.19%)需要光照治疗,2例(9.52%)需要换血。B组新生儿出现黄疸23例(65.7%),其中12例(34.2%)需要光照治疗,无一例需要换血。C组15例(34.09%)出现黄疸,其中1例(2.2%)需要光疗,没有一例需要换血(p3.3 g/dL可能是早期出院安全的)。因此,这有助于识别有风险的新生儿。因此,可以提倡常规测定脐带血白蛋白水平,以跟踪高危新生儿。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cord blood albumin level as a predictor of neonatal physiological jaundice in healthy term neonate
Background: Neonatal jaundice is a very common condition worldwide, occurring in up to 60% of term and 80% of pre-term newborns in the 1st week of life and the most common cause for readmission. The present study was conducted to evaluate the predictive value of umbilical cord blood albumin level for subsequent development of neonatal jaundice in healthy term neonates. The present study is conducted to find usefulness of cord blood albumin in predicting the subsequent development of significant neonatal jaundice. Methods and Methods: This is a hospital-based prospective study conducted in 100 healthy term neonates. Cord blood albumin level estimation was done at birth. Total serum bilirubin estimation was done for all babies with clinically suspected jaundice at 72–96 h of age. The neonates were divided into three Groups A, B, and C based on the cord albumin levels of <2.8 g/dL, 2.8–3.3 g/dL, and >3.3 g/dL, respectively. The main outcome of the study was inferred in terms of serum bilirubin ≥17 mg/dL, newborn required phototherapy, and exchange transfusion. Results: Groups A, B, and C had 21, 35, and 44 newborns, respectively. In Group A, 18 (85.7%) neonates had total bilirubin of >17 mg/dL, of which 16 (76.19%) required phototherapy and 2 (9.52%) needed exchange transfusion. 23 (65.7%) neonates in Group B developed jaundice, of which 12 (34.2%) needed phototherapy and none of them required exchange transfusion. In Group C, 15 (34.09%) developed jaundice of which 1 (2.2%) required phototherapy and none of them required exchange transfusion (p<0.001). Conclusion: Cord blood albumin level ≤2.8 g/dL is a significant risk factor for developing neonatal hyperbilirubinemia that requires early intervention, while cord blood albumin >3.3 g/dL is probably safe for early discharge. Hence, this can help to identify the at-risk neonates. Hence, routine determination of cord blood albumin level can be advocated to keep a track on at-risk neonates.
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