Hyperplastic Polyposis Syndrome

Hyperplastic polyposis is a rare syndrome characterized by the development of multiple colorectal serrated lesions, most often a mixture of hyperplastic polyps and flat serrated adenomas. Patients with hyperplastic polyposis syndrome (HPS) have a high lifetime risk of developing colorectal cancer (up to 50%). However, at colonoscopy the diagnosis is often missed because the flat lesions are not recognized or the endoscopist is simply unaware of this syndrome. Here the author presents three cases with HPS and demonstrates the typical endoscopic features. This article is part of an expert video encyclopedia.