Platelet Rich Fibrin (PRF) : un nouveau biomatériau de cicatrisation

The PRF (platelet rich fibrin) belongs to a new generation of platelet concentrates, with simplified modes of production and without biochemical handling of blood (heparin, EDTA, bovine thrombin, calcium chloride…). In this first article, we were interested in the key molecule of all platelet concentrates, fibrin, in order to emphasize its nature, angiogenic and cicatricial functions and its synergies with cytokines. These data enable us to evaluate the biochemical range of various technologies using fibrin as surgical additive: fibrin adhesives, cPRP (concentrated platelet rich plasma) and PRF (platelet rich fibrin). The tridimensional architecture of fibrin is indeed deeply disturbed by most clinical processes of artificial polymerization, particularly by the massive bovine thrombin addition. Only slow polymerization resulting from the PRF process currently seems to approach a matrix of physiological fibrin, naturally more effective for the migration and the cellular proliferation, and thus for the cicatrization.