应用吸附剂治疗化脓性创面效果的形态学观察(实验研究)

O. Bilyayeva, O. Dyadyk, V. I. Zaritsʹka, Y. Kryzhevskyi
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摘要

目标。通过对创面过程中形态变化的研究,实验证明了新一代应用吸附剂的有效性。方法。根据治疗化脓性伤口的药物,我们将动物分为三组。在主要组(第一组)中,研究对20只大鼠进行了研究,他们使用了一种应用吸附剂,其中包括固定在其基质奥硝唑上的气溶胶(乌克兰实用新型专利№115228)。对照组(II组)10只大鼠,使用已知吸附剂“庆大霉素”,该吸附剂包括:硫酸庆大霉素、l -色氨酸和硫酸锌。对照组(III组)10只大鼠。该组用于治疗化脓性伤口使用10%氯化钠溶液,随后改用软膏“左旋美kol”,其中包括氯霉素和甲尿嘧啶。结果。研究结果显示,主组在第7天已较对照组发现肉芽组织,微循环束新血管大量形成,成纤维细胞增生明显,表明伤口愈合加速。在对照组中,再生过程较慢。结论。病理形态学检查显示,具有吸附特性的药物有助于更快地减轻水肿和炎症,主组应用吸附剂治疗可显著加快结缔组织修复和创面上皮的进程,即与对照组相比,可加快创面愈合进程。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Morphological signs of the effectiveness of application sorbent in the treatment of purulent wounds (experimental study)
Objective. To prove experimentally the effectiveness of a new generation of application sorbent by studying the morphological changes during the wound process. Methods. Depending on the drug used to treat purulent wounds, we divided the animals into three groups. In the main group (group I) the study was performed on 20 rats, they used an application sorbent, which includes aerosil with immobilization on its matrix ornidazole (Patent of Ukraine for utility model № 115228). The comparison group (group II) consisted of 10 rats, which used the known sorbent "Gentaxan", which includes: gentamicin sulfate, L-tryptophan and zinc sulfate. The comparison group (group III) was 10 rats. In this group for the treatment of purulent wounds used 10% sodium chloride solution, followed by a transition to ointment "Levomekol", which includes chloramphenicol and methyluracil. Results. The results of the study show that in the main group already on the seventh day in comparison with the comparison groups was found granulation tissue with a large number of newly formed vessels of the microcirculatory tract and pronounced proliferation of fibroblasts, indicating acceleration of wound healing. In the comparison groups, the regeneration process was slower. Conclusion. Pathomorphological examination revealed that drugs with sorption properties contribute to a faster reduction of edema and inflammation, and treatment with application sorbent used in the main group, significantly accelerates the processes of connective tissue repair and wound epithelization, ie accelerates wound healing processes with comparison groups.
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